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      KCI등재후보

      Synthesis of Methyl Aryloxy Gallates and Their Inhibitory Activity of NF-κB and Cytotoxicity

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      https://www.riss.kr/link?id=A101777942

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      다국어 초록 (Multilingual Abstract)

      A series of novel diaryl ether analogs possessing gallate moiety were synthesized and NF-κB
      inhibitory activity and cytotoxicity were evaluated. NF-κB luciferase activities in prostate LNCaP and colon cancer
      HCT116 cells showed that 2a, 2c, 2d, 2g, and 2i had potent to moderate inhibitory activities. In addition, 2a exerted
      more potent cytotoxicity than the reference compound, obovatol, against prostate (LNCaP and PC-3) and colon
      cancer (HCT116 and SW620) cells.
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      A series of novel diaryl ether analogs possessing gallate moiety were synthesized and NF-κB inhibitory activity and cytotoxicity were evaluated. NF-κB luciferase activities in prostate LNCaP and colon cancer HCT116 cells showed that 2a, 2c, 2d, 2g...

      A series of novel diaryl ether analogs possessing gallate moiety were synthesized and NF-κB
      inhibitory activity and cytotoxicity were evaluated. NF-κB luciferase activities in prostate LNCaP and colon cancer
      HCT116 cells showed that 2a, 2c, 2d, 2g, and 2i had potent to moderate inhibitory activities. In addition, 2a exerted
      more potent cytotoxicity than the reference compound, obovatol, against prostate (LNCaP and PC-3) and colon
      cancer (HCT116 and SW620) cells.

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