위분문부 장상피화생은 위식도역류질환 혹은 Helicobacter pylori 감염과 연관이 있는가? = Is Intestinal Metaplasia of the Gastric Cardia associated with Gastroesophageal Reflux Disease or Helicobacter pylori Infection?

다국어 초록 (Multilingual Abstract)

Background/Aims: It is unknown whether cardia intestinal metaplasia (IM) is associated with gastroesophageal reflux disease (GERD) or Helicobacter pylori (H. pylori) infection. The aim of the present study was to investigate the role of GERD and H. pylori infection in the development of cardia IM. Methods: Thirty-seven consecutive patients with reflux esophagitis were studied. Thirty age-and sex-matched, asymptomatic subjects were studied as a control group. Two biopsy specimens were obtained from antrum, body, fundus and cardia, respectively. All specimens were stained with H&E, Alcian-blue and Giemsa. The severity of gastritis was graded according to the updated Sydney system. Results: Carditis in controls was more severe than that in patients with reflux esophagitis. The prevalence of H. pylori infection was correlated with degree of carditis in each group (p<0.05). The prevalence of cardia IM was not significantly different between patients with reflux esophagitis (24.3%) and controls (46.7%). However, H. pylori infection was more common in subjects with cardia IM than in subjects without cardia IM in each group (p<0.05). Conclusions: Cardia IM may be associated with H. pylori infection, but not with GERD.