수종 용제 중 퀘르세틴의 용해성 및 안정성 = Solubility and Physicochemical Stability of Quercetin in Various Vehicles

다국어 초록 (Multilingual Abstract)

The solubility and stability of quercetin in various vehicles were determined. The soubility of quercetin at 28℃ increased in the rank order of isopropyl myristate < oleyl alcohol < propylene glycol monocaprylate (PGMC) < polyethylene glycol-8 glyceryl linoleate < caprylocaproyl macrogol-6 glycerides < dietylene glycon mono ethy1 ether(DGME). The addition of DGME to non-aqueous vehicles such as PGL and PGMC markedly increased the solubility of quercetin. From the stability studies, it was found that quercetin was unstable due to rapid oxidation by dissoved oxygen. The addition of a combination of ascorbic acid and edetic acid (EDTA) at 0.1% markedly decreased the degrandation rates of quercetin in 40% polyethylene glycon 400 in saline. Quercetin was relatively unstable in non-aqueous vehicles such as PGL and PGMC alone, and PGL-PGMC co-solvent. The degradation of quercetin in such non-aqueous vehicles was fast, depending on temperature. The addition of butylated hydroxytoluene, butylated hydroxyanisole, citric acid and/or EDTA at 0.1% was effective in retarding the degradation of quercetin.

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