담즙산 및 합성유도체가 여러 암세포에서 세포자멸사를 유도하여 항암활성을 보인다고 밝혀졌지만 뼈육종세포에서의 세 포자멸사 유도활성은 보고된 바 없다. 본 연구는 담즙산 유도체들...
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https://www.riss.kr/link?id=A77004978
2004
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Synthetic bile acid ; Apoptosis ; Anticancer effect ; Osteosarcoma cells ; 합성담즙산 ; 세포자멸사 ; 항암효과 ; 벼육종세포
510
KCI등재,ESCI
학술저널
449-457(9쪽)
2
0
상세조회0
다운로드국문 초록 (Abstract)
담즙산 및 합성유도체가 여러 암세포에서 세포자멸사를 유도하여 항암활성을 보인다고 밝혀졌지만 뼈육종세포에서의 세 포자멸사 유도활성은 보고된 바 없다. 본 연구는 담즙산 유도체들...
담즙산 및 합성유도체가 여러 암세포에서 세포자멸사를 유도하여 항암활성을 보인다고 밝혀졌지만 뼈육종세포에서의 세
포자멸사 유도활성은 보고된 바 없다. 본 연구는 담즙산 유도체들이 뼈육종세포에 세포자멸사를 유도하는지를 알아보고 그 기작을 연구하기 위하여 수행되었다. UDCA 합성 유도체와는 달리 CDCA 합성유도체는 뼈육종세포의 사망을 유도하였다.
CDCA 유도체 중 HS-1200을 선택하여 세포자멸사 기전을 연구하였다. HS-1200은 핵의 농축, cytochrome c 방출, Bax/Bcl-xL분율 변화, caspase-3의 활성화 및 CAD와 PARP 분절 등을 관찰되었다. 비록 더 많은 연구가 필요하지만 본 시험관 연구 자료는 합성담즙산 유도체 투여가 뼈육종의 치료전략이 될 수 있음을 시사한다.
다국어 초록 (Multilingual Abstract)
Bile acids and synthetic its derivatives induced apoptosis in various kinds of cancer cells and had anticancer effects. However, it wasn’t discovered those materials have apoptosis induced effects on osteosarcoma cells. The present study was done t...
Bile acids and synthetic its derivatives induced apoptosis in various kinds of cancer cells and had anticancer effects.
However, it wasn’t discovered those materials have apoptosis induced effects on osteosarcoma cells. The present study was done to examine the synthetic bile acid derivatives induced apoptosis on osteosarcoma cells and such these apoptosis events.
The synthetic bile acid derivatives, chenodeoxycholic acid (CDCA) induced the cell death on human osteosarcoma
(HOS) cells contrary to ursodeoxycholic acid (UDCA). HS-1200, a synthetic derivative of CDCAs, was chosen to
experiment apoptosis events in HOS cells. HOS cells treated with HS-1200 showed nucleus condensation, cytochrom c release, Bax/Bcl-xL alteration, activation of caspase-3 and caspase-activated deoxyribonuclease (CAD), and
degradation of poly (ADP-ribose) polymerase (PARP).
Though this study needs more investigations, these in vitro data suggest that treatment of the synthetic bile acid derivatives can give medical therapy on HOS cells.
참고문헌 (Reference)
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8 "Mitochondrial cytochromec release in apoptosis occurs upstream of DEVD-specificcaspase activation and independently of mitochondrial transmembranedepolarization" 17 : 37-49, 1998.
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1 "the executioners of apoptosis" 326 : 1-16, 1997.
2 "polymerase in the cellular responseto DNA damage" 4-15, 1985.
3 "The mitochondrialdeath/life regulator in apoptosis and necrosis" 60 : 619-642, 1998.
4 "Synthetic chenodeoxycholic acidderivative HS-1200-induced apoptosis of p815 mastocytoma cellsis augmented by co-treatment with lactacystin" 14 : 219-225, 2003.
5 "Novel bile acid derivatives induce apoptosis via a p53-independentpathway in human breast carcinoma cells" 163 : 83-93, 2001.
6 "Molecular characterization of mitochondrial apoptosis-inducing factor" 397 : 441-446, 1999.
7 "Mitochondrialdepolarization accompanies cytochrome c release duringapoptosis in PC6 cells" 274 : 5654-5658, 1999.
8 "Mitochondrial cytochromec release in apoptosis occurs upstream of DEVD-specificcaspase activation and independently of mitochondrial transmembranedepolarization" 17 : 37-49, 1998.
9 "Mitochondrial control of apoptosis" 18 : 44-51, 1997.
10 "Mitochondria and apoptosis" 281 : 1309-1312, 1998.
11 "Macromolecular substrates for theICE-like proteases during apoptosis" 64 : 50-54, 1997.
12 "Inhibition of initiation of simian virus 40 DNA replication invitro by the ursodexocycholic acid and its derivatives" 146 : 147-153, 1999.
13 "Induction of apoptosisby bile acids in HepG2 human hepatocellular carcinoma cells" 1 : 107-115, 1997.
14 "Induction of apoptosis in HepG2 human hepatocellular carcinomacells by a novel derivative of ursodeoxycholic acid(UDCA)" 20 : 29-33, 1997.
15 "Evolutionary conservation of a genetic pathway of programmedcell death" 60 : 4-11, 1996.
16 "Druginducedapoptosis in osteosarcoma cell lines is mediated by caspaseactivation independent of CD95-receptor/ligand interaction" 18 : 10-17, 2000.
17 "Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation" 31 : 111-118, 1998.
18 "Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei" 154 : 3788-3795, 1995.
19 "Cytochrome c: can't live with it--can't live without it" 91 : 559-562, 1997.
20 "Cleavage of poly polymerase by a proteinasewith properties like ICE" 346-371 347, 1994.
21 "Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma" 45 : 199-206, 2000.
22 "Chromatin condensation during apoptosis in accompanied bydegradation of lamin A±B without enhanced activation of cdc2kinase" 827-837, 1994.
23 "Cell death in development" 96 : 245-254, 1999.
24 "Caspase: enemies within" 281 : 1312-1316, 1998.
25 "Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidantsand blockers of the mitochondrial permeability transition" 33 : 616-626, 2001.
26 "Apoptotic activity of novel bile acid derivatives in humanleukemic T cells through the activation of caspases" 18 : 979-984, 2001.
27 "Apoptosis. Molecules and mechanisms" 457 : 217-236, 1999.
28 "Apoptosis of human tumor cells by chemotherapeuticanthracyclines is enhanced by Bax overexpression" 40 : 263-272, 1999.
29 "Anti-angiogenicactivity of ursodeoxycholic acid and its derivatives" 113 : 117-122, 1997.
30 "An APAF-1, cytochrome c multimericcomplex is a functional apoptosome that activates procaspase-9" 274 : 11549-11556, 1999.
31 "A novel ursodeoxycholicacid derivative induces apoptosis in human MCF-7breast cancer cells" 5 : 1-6, 1999.
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학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2022 | 평가예정 | 계속평가 신청대상 (계속평가) | |
2020-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
2019-12-01 | 평가 | 등재후보 탈락 (계속평가) | |
2018-12-01 | 평가 | 등재후보로 하락 (계속평가) | ![]() |
2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2010-02-02 | 학술지명변경 | 한글명 : 대한해부학회지 -> Anatomy and Cell Biology외국어명 : The Korean Journal of Anatomy -> Anatomy and Cell Biology | ![]() |
2008-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
2007-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | ![]() |
2006-01-01 | 평가 | 등재후보로 하락 (등재유지) | ![]() |
2004-01-01 | 평가 | 등재 1차 FAIL (등재유지) | ![]() |
2001-07-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
1999-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.15 | 0.15 | 0.1 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.1 | 0.09 | 0.223 | 0.03 |