두경부암에서 인간유듀종바이러스 : 종양형성 = HPV in Head and Neck Cancer : Oncogenesis

국문 초록 (Abstract)

HPV 양성 두경부 편평상피암에서 바이러스 종양유전자의 역할과 환자의 종양억제유전자 상호작용에 관한 더많은 분자학적 연구는 HPV양성 두경부암과 발암물질관련 두경부암에서 새로운 치료법 개발에 도움이 될 것으로사료된다.

참고문헌 (Reference)

1 O’Regan EM, "p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas" 39 (39): 452-458, 2008

2 Olivier M, "The IARC TP53 database: new online mutation analysis and recommendations to users" 19 (19): 607-614, 2002

3 Wentzensen N, "Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract" 64 (64): 3878-3884, 2004

4 Ragin CC, "Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis" 121 (121): 1813-1820, 2007

5 Strati K, "Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer" 67 (67): 11585-11593, 2007

6 Uversky VN, "Protein intrinsic disorder and human papillomaviruses: increased amount of disorder in E6 and E7 oncoproteins from high risk HPVs" 5 (5): 1829-1842, 2006

7 Koskinen WJ, "Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck" 107 (107): 401-406, 2003

8 Park JS, "Physical status and expression of HPV genes in cervical cancers" 65 (65): 121-129, 1997

9 McLaughlin-Drubin ME, "Oncogenic activities of human papillomaviruses" 143 (143): 195-208, 2009

10 Perez-Ordonez B, "Molecular biology of squamous cell carcinoma of the head and neck" 59 (59): 445-453, 2006

11 Perrone F, "Molecular and cytogenetic subgroups of oropharyngeal squamous cell carcinoma" 12 (12): 6643-6651, 2006

12 Ragin CC, "Mapping and analysis of HPV16 integration sites in a head and neck cancer cell line" 110 (110): 701-709, 2004

13 Merkley MA, "Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes" 7 : 29-, 2009

14 Applebaum KM, "Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer" 99 (99): 1801-1810, 2007

15 Westra WH, "Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck" 14 (14): 366-369, 2008

16 Hafner N, "Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts" 27 (27): 1610-1617, 2008

17 Jeon S, "Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells" 69 (69): 2989-2997, 1995

18 Butz K, "Induction of the p53-target gene GADD45 in HPV-positive cancer cells" 18 (18): 2381-2386, 1999

19 Nakao Y, "Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation" 75 (75): 1410-1416, 1997

20 Shintani S, "Inactivation of the p14(ARF), p15(INK4B) and p16 (INK-4A) genes is a frequent event in human oral squamous cell carcinomas" 37 (37): 498-504, 2001

21 Park NH, "Immortalization of normal human oral keratinocytes with type 16 human papillomavirus" 12 (12): 1627-1631, 1991

22 Snijders PJ, "Human papillomavirus(HPV) type 16 and 33 E6/E7 region transcripts in tonsillar carcinomas can originate from integrated and episomal HPV DNA" 73 : 2059-2066, 1992

23 Kreimer AR, "Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review" 14 (14): 467-475, 2005

24 Mellin H, "Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer" 102 (102): 152-158, 2002

25 Chung CH, "Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications" 15 (15): 6758-6762, 2009

26 Munger K, "Human papillomavirus immortalization and transformation functions" 89 (89): 213-228, 2002

27 Hobbs CG, "Human papillomavirus and head and neck cancer: a systematic review and meta-analysis" 31 (31): 259-266, 2006

28 Schiffman M, "Human papillomavirus and cervical cancer" 370 (370): 890-907, 2007

29 Mellin H, "Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse, and survival" 89 (89): 300-304, 2000

30 Vu HL, "HPV-induced oropharyngeal cancer, immune response and response to therapy" 288 (288): 149-155, 2010

31 Goon PK, "HPV & head and neck cancer: a descriptive update" 1 : 36-, 2009

32 Wilting SM, "Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck" 2 : 32-, 2009

33 Richards KL, "Genome-wide hypomethylation in head and neck cancer is more pronounced in HPV-negative tumors and is associated with genomic instability" 4 (4): e4941-, 2009

34 Braakhuis BJ, "Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus" 96 (96): 998-1006, 2004

35 Schlecht NF, "Gene expression profiles in HPV-infected head and neck cancer" 213 (213): 283-293, 2007

36 Klussmann JP, "Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus" 162 (162): 747-753, 2003

37 Allen CT, "El-Mofty SK, Haughey BH, Nussenbaum B. Human papillomavirus and oropharynx cancer: biology, detection and clinical implications" 120 (120): 1756-1772, 2010

38 Kumar B, "EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer" 26 (26): 3128-3137, 2008

39 Rampias T, "E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells" 101 (101): 412-423, 2009

40 Gillison ML, "Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers" 100 (100): 407-420, 2008

41 Franceschi S, "Comparison of the effect of smoking and alcohol drinking between oral and pharyngeal cancer" 83 (83): 1-4, 1999

42 Shi W, "Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma" 27 (27): 6213-6221, 2009

43 Reimers N, "Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer" 120 (120): 1731-1738, 2007

44 Fakhry C, "Clinical implications of human papillomavirus in head and neck cancers" 24 (24): 2606-2611, 2006