증례 : 혈액종양 ; 임신과 동반된 원발성 종격동 거대 B세포 림프종에서 Rituximab 치료 = Case Reports : Hemato-oncology ; Rituximab Plus CHOP for the Treatment of Primary Mediastinal Large B Cell Lymphoma in a Pregnant Woman

국문 초록 (Abstract)

저자들은 임신 중기에 진단된 PMLBCL 환자를 성공적으로 치료하였으며, 중기 및 후기 임신과 관련한 R-CHOP 복합 항암화학요법의 효과와 안전성을 입증하였다. 본 증례는 우리나라에서 임신 여성에게 시행한 R-CHOP 요법의 사용에 대한 첫 보고임에 의의를 두는 바이다.

다국어 초록 (Multilingual Abstract)

A 33-year-old woman developed primary mediastinal large B-cell lymphoma (PMLBCL) during the second trimester of pregnancy. She was immediately treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). After the third cycle of R-CHOP, she delivered a healthy baby by Caesarian section. She was in complete response after she finished all courses of treatment, and the rituximab-containing chemotherapy during pregnancy induced no adverse effect in the fetus. Thus, R-CHOP appears to be an effective, safe treatment option for PMLBCL encountered during the second and third trimesters of pregnancy. To our knowledge, this is the first report of the use of rituximab plus CHOP in a pregnant woman in Korea. (Korean J Med 2011;80:S273-S277)

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