Depression and Anxiety in Korean Patients with Chronic Obstructive Pulmonary Disease = Depression and Anxiety in Korean Patients with Chronic Obstructive Pulmonary Disease

다국어 초록 (Multilingual Abstract)

Background: Depression and anxiety are common comorbidity in COPD patients, and they could have potential impact on clinical outcomes of COPD. Objective: We assessed the prevalence of depression and anxiety in Korean COPD patients, and also investigated whether co-morbid depression or anxiety show clinical differences in the course of COPD. Methods: Using Korean Obstructive Lung Disease (KOLD) Cohort from 15 university hospitals in Korea, we analyzed the prevalence of depression and anxiety by using Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). We also compared demographic data, comorbidity, lung function, frequency of acute exacerbation, mortality related or unrelated with COPD, emphysema index and quality of life measured with St George Respiratory Questionnaire for COPD patients (SGRQC) between depression or anxiety patients with non-depression or non-anxiety patients, respectively. Results: Among 217 patients with COPD, the prevalence of depression and anxiety were 37.8% and 27.2%, each. Depression and anxiety were closely correlated with each other. Patients with depression or anxiety had higher BODE index, higher SGRQC score and more frequent acute exacerbation for following 3 years. After controlling for confounders including age, sex and BODE index, presence of depression or anxiety had no significant impact on frequency of acute exacerbation. Conclusion: Based on BDI and BAI, depression and anxiety are common in Korean patients with COPD, and may influence variable aspects of COPD.