조현병/조현정동장애 환자에서 1년간의 Clozapine 투여가 혈소판 활성도에 미치는 영향에 관한 후향적 연구 = A Retrospective Study on the Effect of 1-Year Clozapine Administration on Platelet Activity in Patients with Schizophrenia or Schizoaffective Disorder

국문 초록 (Abstract)

연구목적클로자핀은 뇌심혈관 질환의 발생가능성을 높이는 것으로 알려져 있으며, 혈소판의 활성화 정도는 뇌심혈관 질환의 발생과 관련이 있을 것으로 생각되어왔다. 저자들은 이전 연구에서 단기간의 클로자핀 투여 후 혈소판 활성도가 증가함을 관찰하였다. 본 연구는 이에 대한 후속 연구로 클로자핀을 1년의 기간 동안 장기간 지속투여하였을 때, 혈소판 활성도에 어떤 영향을 미치는지를 알아보기 위해 시행하였다.
방 법조현병 혹은 조현정동장애의 치료를 위해 최소 1년의 기간 동안 지속적으로 클로자핀을 투여 받은 환자들의의무기록을 후향적으로 검토하였다. 혈소판의 활성도는 평균혈소판요소 값을 이용하여 측정하였다.
결 과총 24명의 환자를 대상으로 하였고, 연구 대상자 중 남성은 9명(37.5%), 여성은 15명(62.5%) 였다. 윌콕슨부호-순위검정에서 초기 및 1년 경과 시점에서의 평균혈소판요소 값 사이의 유의한 변화는 관찰되지 않았다.
결 론1년간의 지속적인 클로자핀 투여에도 평균혈소판요소의 유의한 변화가 관찰되지 않았다. 단기간의 클로자핀 투여 시 평균혈소판요소 값에 현저한 저하를 관찰하였던 저자들의 이전의 연구 결과를 함께 고려해 볼 때, 본 연구의 결과는 클로자핀 투여 기간에 따라 혈소판의 활성도가 변화할 가능성을 시사한다.

다국어 초록 (Multilingual Abstract)

Objectives：Clozapine has been known to increase the possibility of developing cardio/cerebrovascular diseases, and the platelet activation has been deemed to be related to the occurrence of them. In author’s previous study, we observed the increase of platelet activity with short-term clozapine administration. This study was conducted, as a follow-up study, to investigate the effect of clozapine on the platelet activity when administered continuously for long-term period of time of 1 year.
Methods：The medical records of the patients with schizophrenia or schizoaffective disorder who were treated with clozapine for 1 year were retrospectively reviewed. The degree of platelet activation was assessed by measuring the mean platelet component.
Results：Total of 24 patients were enrolled. 9 of them (37.5%) were male and 15 of them (62.5%) were female.
In the Wilcoxon sign-ranks test, no significant change was observed between the mean platelet factor values at the beginning and at the end of one year.
Conclusions：No significant changes of mean platelet activity were observed after continued administration of clozapine for 1 year. Considering the author’s previous findings that observed a prominent decrease of mean platelet component after short-term clozapine administration, the result of this study suggests the possibility that the activity of the platelet may change depending on the duration of the clozapine administration.

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