Suspected Case of Exocrine Pancreatic Insufficiency in a Bengal Tiger

다국어 초록 (Multilingual Abstract)

A 1-year-old, female Bengal tiger (Panthera tigris tigris) presented signs of weight loss and dark browncoloreddiarrhea. On fecal examination, numerous intact and broken red blood cells were found, but both parasitesand inflammatory signs were absent. No significant findings were seen in serum biochemistry profiles, includingelectrolytes, with negative feline pancreatic lipase immunoreactivity (fPLI). Diagnostic kits using feces or peripheralblood were negative for feline parvovirus, feline coronavirus, feline immunodeficiency virus, and feline leukemia virus.
Based on the result of feline trypsin-like immunoreactivity (fTLI) concentration (4.6 μg/L), the tiger was provisionallydiagnosed to have exocrine pancreatic insufficiency (EPI). After this diagnosis, pancreatic enzymes were prescribed.
The feces of the tiger returned to normal form and her weight was increasing. EPI is uncommon and not describedextensively in Felidae, including domestic cats. Feline EPI is associated with a variety of non-specific signs and itshould be considered in the differential diagnosis of cases presenting with weight loss, diarrhea, and other gastrointestinalsigns. In this case, the patient was strongly suspected to have EPI based on the very low fTLI concentration, thoughthe concentration of fTLI in tigers has not yet been determined. This is the first report to present a suspected EPIcase in Bengal tigers.

참고문헌 (Reference)

1 Steiner JM, "Validation of a radioimmunoassay for feline trypsin-like immunoreactivity (fTLI) and serum cobalamin and folate concentrations in cats with exocrine pancreatic insufficiency" 9 : 193-, 1995

2 Steiner JM, "Textbook of Veterinary Internal Medicine" Saunders Elsevier 1296-1325, 2010

3 Xenoulis PG, "Suspected isolated pancreatic lipase deficiency in a dog" 21 : 1113-1116, 2007

4 Simpson KW, "Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal disease" 15 : 26-32, 2001

5 Steiner JM, "Serum feline trypsin-like immunoreactivity in cats with exocrine pancreatic insufficiency" 14 : 627-629, 2000

6 DiMagno EP, "Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency" 288 : 813-815, 1973

7 Ruaux CG, "Metabolism of amino acids in cats with severe cobalamin deficiency" 62 : 1852-1858, 2001

8 Thompson KA, "Feline exocrine pancreatic insufficiency: 16 cases (1992-2007)" 11 : 935-940, 2009

9 Williams DA, "Fecal proteolytic activity in clinically normal cats and in a cat with exocrine pancreatic insufficiency" 197 : 210-212, 1990

10 Kook PH, "Exocrine pancreatic insufficiency in the cat" 153 : 19-25, 2011

11 Steiner JM, "Exocrine Pancreatic Insufficiency in the Cat" 27 : 113-116, 2012

12 Kennedy OC, "Exocrine Pancreatic Insufficiency in Dogs and Cats: Online Support for Veterinarians and Owners" 27 : 117-122, 2012

13 Larsen S, "Diabetes mellitus secondary to chronic pancreatitis" 40 : 153-162, 1993

14 Steiner JM, "Development and validation of an enzyme-linked immunosorbent assay for feline trypsin-like immunoreactivity" 61 : 620-623, 2000

15 Packer RA, "D-lactic acidosis secondary to exocrine pancreatic insufficiency in a cat" 19 : 106-110, 2005

16 Williams DA, "Current veterinary therapy xii: small animal practice" WB Saunders 732-735, 1995

17 Steiner JM, "Consultations in Feline Medicine" Saunders Elsevier 225-231, 2010

18 Williams DA, "Comparison of methods for assay of fecal proteolytic activity" 19 : 20-24, 1990

19 Fleeman LM, "Chronic, subclinical, exocrine pancreatic disease is common in diabetic dogs" 18 : 402-, 2004