<P><B>Purpose</B></P><P>This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer.</P>&...
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=A107728304
2018
-
KCI등재,SCOPUS,SCIE
학술저널
161-167(7쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Purpose</B></P><P>This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer.</P>&...
<P><B>Purpose</B></P><P>This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer.</P><P><B>Methods</B></P><P>This retrospective study analyzed 42 patients who were randomly assigned to receive a FOLFOX regimen with or without KRG. Spleen volume change was assessed by computed tomography scans measured before surgery (presurgery volume) and 3 weeks after cessation of the 12th cycle of FOLFOX (postchemotherapy volume).</P><P><B>Results</B></P><P>All patients showed increased spleen volume. No difference was observed in median presurgery and postchemotherapy volume between the KRG and control groups. However, a ratio defined as postchemotherapy volume divided by presurgery volume was significantly lower in the KRG group than the control group (median, 1.38 [range, 1.0–2.8] in KRG group vs. median, 1.89 [range, 1.1–3.0] in control group, P = 0.028). When splenomegaly was defined as a >61% increase in spleen volume, the rate of splenomegaly was significantly lower in the KRG group than the control group (28.6% <I>vs</I>. 61.9%, P = 0.03). KRG consumption was inversely associated with developing splenomegaly in multivariate analysis.</P><P><B>Conclusion</B></P><P>Adding KRG during FOLFOX chemotherapy for colon cancer might protect against oxaliplatin-induced splenomegaly. The protective effect of Korean red ginseng should be investigated with further research.</P>
Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer
Use of direct antiviral agents in liver transplant recipients with hepatitis C virus in Korea
Clinical implication of spontaneous gastrointestinal perforation in pediatric patients