1 "is expressed during normal mousedevelopment" a zinc finger transcriptionfactor and oncogene 91-102, 1993
2 "is a suppressor of Hedgehogsignaling and is deleted in human medulloblastoma" Mincione C 10833-10838, 2004
3 "cyclinexpression and sustained cell cycle progression in mammalianneuronal precursors" 9055-9067, 2000
4 "cellular processesthat project to the principal signaling center in Drosophilaimaginal discs" 599-607, 1999
5 "and spinalcord identity in gastrula stage chick embryos" 689-23 702, 1999
6 "and differentiation during mouse lung organogenesis" 214-231, 2004
7 "a novel sterol-sensing domain proteindedicated to the release of cholesterol-modified hedgehogfrom signaling cells" 803-815, 1999
8 "a novel kinesinrelatedprotein in the Hedgehog signaling pathway" 235-245, 1997
9 "a new role for Sonichedgehog" nta p : 3927-128 3936, 2001
10 "a member of a familyof putative signaling molecules is implicated in the regulationof CNS polarity" 1417-1430, 1993
11 "Vitronectin regulatesSonic hedgehog activity during cerebellum developmentthrough CREB phosphorylation" 1481-128 92, 2001
12 "Transient establishment of anteroposteriorpolarity in the zebrafish pectoral fin bud in the absence ofsonic hedgehog activity" ard c : 4817-126 4826, 1999
13 "Transcriptional profiling of the Sonic hedgehog response acritical role for N-myc in proliferation of neuronal precursors" 7331-7336, 2003
14 "Tissue repair and stemcell renewal in carcinogenesis" 324-432 331, 2004
15 "Thecholesterol membrane anchor of the Hedgehog proteinconfers stable membrane association to lipid-modifiedproteins" 8531-8536, 2004
16 "The whereabouts of amorphogen direct evidence for short- and graded longrangeactivity of hedgehog signaling peptides" 364-386, 2001
17 "The subcellular localization and activityof Drosophila cubitus interruptus are regulated at multiplelevels" 5097-126 5106, 1999
18 "The sterol-sensingdomain of Patched protein seems to control Smoothenedactivity through Patched vesicular trafficking" 601-607, 2001
19 "The product of hedgehog autoproteolyticcleavage active in local and long-range signalling" 363-366, 1995
20 "The morphogen sonic hedgehog is an axonal chemoattractantthat collaborates with netrin-1 in midline axon guidance" 11-23, 2003
21 "The basic helix-loop-helix factor olig2 isessential for the development of motoneuron and oligodendrocytelineages" 1157-1163, 2002
22 "The bHLH transcription factorOlig2 promotes oligodendrocyte differentiation in collaborationwith Nkx2" 791-31 807, 2001
23 "The SmoA1 mouse model reveals that notchsignaling is critical for the growth and survival of sonichedgehog-induced medulloblastomas" 7794-7800, 2004
24 "The Drosophila hedgehog geneis expressed specifically in posterior compartment cells andis a target of engrailed regulation" 2635-2645, 1992
25 "Temporal requirementfor hedgehog signaling in ventral telencephalic patterning" 5031-131 5040, 2004
26 "Suppressor of fused opposes hedgehog signaltransduction by impeding nuclear accumulation of the activatorform of Cubitus interruptus" 4001-127 4010, 2000
27 "Subcellularlocalization of the segment polarity protein patchedsuggests an interaction with the wingless reception complexin Drosophila embryos" 987-120 998, 1994
28 "Stability and association of Smoothened Costal2 and Fusedwith Cubitus interruptus are regulated by Hedgehog" 907-913, 2003
29 "Specification of neuronal fates in the ventralneural tube" 43-49, 2001
30 "Specification of neuronal cell types in theventral spinal cord is mediated by antagonistic interactionbetween Shh and Gli3" 979-985, 2000
31 "Spatial patternof sonic hedgehog signaling through Gli genes duringcerebellum development" 5581-131 5590, 2004
32 "Sonic hedgehogsignaling is required during the appearance of spinal cordoligodendrocyte precursors" 2419-126 2429, 1999
33 "Sonic hedgehogmediates the polarizing activity of the ZPA" Tabin C 1401-1416, 1993
34 "Sonic hedgehog signaling is required for expansion of granuleneuron precursors and patterning of the mouse cerebellum" 393-410, 2004
35 "Sonic hedgehog regulatesadult neural progenitor proliferation in vitro and invivo" 21-27, 2003
36 "Sonic hedgehog regulates thegrowth and patterning of the cerebellum" 3089-126 3100, 1999
37 "Sonic hedgehog promotesrod photoreceptor differentiation in mammalianretinal cells in vitro" 6277-6288, 1997
38 "Sonic hedgehog isrequired for progenitor cell maintenance in telencephalicstem cell niches" 937-39 950, 2003
39 "Sonic hedgehog inducesthe proliferation of primitive human hematopoietic cells viaBMP regulation" nat immu (nat immu): 172-80, 2001
40 "Smoothenedmutants reveal redundant roles for Shh and Ihh signalingincluding regulation of L/R symmetry by the mouse node" 781-92, 2001a
41 "Smoothened transduces Hedgehog signal byphysically interacting with Costal2/Fused complex throughits C-terminal tail" 2709-2720, 2003
42 "Shaggy/GSK3antagonizes Hedgehog signalling by regulating Cubitusinterruptus" 548-416 552, 2002
43 "Secretion and localizedtranscription suggest a role in positional signaling forproducts of the segmentation gene hedgehog" 33-50, 1992
44 "Retinal ganglion cell-derived sonic hedgehogsignaling is required for optic disc and stalk neuroepithelialcell development" 2967-130 2980, 2003
45 "Repression of ci-D in posterior compartmentsof Drosophila by engrailed" 1068-1077, 1990
46 "Regulation of retinal ganglion cell productionby Sonic hedgehog" 943-128 957, 2001b
47 "Regulation of patched by sonic hedgehog inthe developing neural tube" Tabin CJ 9346-9351, 1996
48 "Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1" Incardona JP 12044-12049, 2000
49 "Reading the Hedgehog morphogen gradient bymeasuring the ratio of bound to unbound Patched protein" 76-431 80, 2004
50 "Rab23 is an essentialnegative regulator of the mouse Sonic hedgehog signallingpathway" -412, 194-1982001
51 "Purkinje-cell-derived Sonic hedgehog regulatesgranule neuron precursor cell proliferation in the developingmouse cerebellum" 445-448, 1999
52 "Proteolytic processingyields two secreted forms of sonic hedgehog" 2294-303, 1995
53 "Proteolysis that is inhibited by hedgehog targets Cubitusinterruptus protein to the nucleus and converts it to arepressor" 1043-1053, 1997
54 "Proteolysis of the Hedgehog signalingeffector Cubitus interruptus requires phosphorylation byGlycogen Synthase Kinase 3 and Casein Kinase 1" 823-835, 2002
55 "Protein kinase A antagonizes Hedgehogsignaling by regulating both the activator and repressorforms of Cubitus interruptus" 2828-2837, 1999
56 "Proneural genes and thespecification of neural cell types" 517-530, 2002
57 "Posttranscriptional regulation of smoothenedis part of a self-correcting mechanism in the Hedgehogsignaling system" 457-465, 2000
58 "Persistent progenitors at the retinal margin ofptc±/- mice" 229-237, 2004
59 "Pax6 controlsprogenitor cell identity and neuronal fate in response tograded Shh signaling" 169-180, 1997
60 "Patterning of the zebrafishretina by a wave of sonic hedgehog activity" ard c : 2137-289 2139, 2000
61 "Patterning cell types in the dorsal spinalcord" 289-297, 2003
62 "Patterning activities of vertebratehedgehog proteins in the developing eye and brain" 944-5 955, 1995
63 "Patched1 interactswith cyclin B1 to regulate cell cycle progression" 2214-2223, 2001
64 "Patched acts catalyticallyto suppress the activity of Smoothened" 892-418 897, 2002
65 "Palmitoylationis required for the production of a soluble multimericHedgehog protein complex and long-range signaling invertebrates" 641-659, 2004a
66 "Order out of chaos assembly of ligand bindingsites in heparan sulfate" 435-471, 2002
67 "Nuclear trafficking of Cubitus interruptus in the transcriptionalregulation of Hedgehog target gene expression" 305-316, 1999
68 "Nuclear import of cubitus interruptus isregulated by hedgehog via a mechanism distinct from Cistabilization and Ci activation" 3131-127 3139, 2000
69 "Neuronal specification in the spinal cord" 20-29, 2000
70 "Nat Cell Biol in press" 2004
71 "NKX2 gene expressionin neuroectoderm but not in mesendodermally derivedstructures depends on sonic hedgehog in mouse embryos" 210 : 47-50, 2000
72 "Mutations in the sterol-sensing domain ofPatched suggest a role for vesicular trafficking in Smoothenedregulation" 608-613, 2001
73 "Mutations in the human Sonic Hedgehoggene cause holoprosencephaly" 357-360, 1996
74 "Mutations in SUFU predisposeto medulloblastoma" 306-310, 2002
75 "Mouse Gli1 mutants are viablebut have defects in SHH signaling in combination with aGli2 mutation" 1593-127 1605, 2000
76 "Molecular organization and embryonic expressionof the hedgehog gene involved in cell-cell communicationin segmental patterning of Drosophila" 957-971, 1992
77 "Molecular Biology of theCell" Garland Publishing Inc 54-79, 1994
78 "Missense mutations in SMOHin sporadic basal cell carcinomas of the skin and primitiveneuroectodermal tumors of the central nervous system" 1798-1803, 1998
79 "Midline signalling is required for Pax gene regulation andpatterning of the eyes" 3267-121 3278, 1995
80 "Interactions with Costal2and suppressor of fused regulate nuclear translocation andactivity of cubitus interruptus" 2893-2905, 2000b
81 "Inductive interactions direct earlyregionalization of the mouse forebrain" 2709-124 2718, 1997
82 "Induction of oligodendrocyte progenitorsin the trunk neural tube by ventralizing signals effects of notochord and floor plate grafts and of sonichedgehog" 13-32, 1996
83 "Identification of a palmitic acidmodifiedform of human Sonic hedgehog" 14037-14045, 1998
84 "Identification of a functional interactionbetween the transmembrane protein Smoothened and thekinesin-related protein Costal2" asca (asca): 1998-20032003
85 "Holoprosencephaly in The Metabolic andMolecular Bases of Inherited Disease" McGraw-Hill Inc 6203-6230, 2001
86 "Hedgehogsignal transduction via Smoothened association with acytoplasmic complex scaffolded by the atypical kinesin" 1261-2 1274, 2003
87 "Hedgehog-regulated processingof Gli3 produces an anterior/posterior repressor gradient inthe developing vertebrate limb" 423-434, 2000a
88 "Hedgehog-dependentoligodendrocyte lineage specification in the telencephalon" 2545-128 2554, 2001
89 "Hedgehog signaling in animal development" paradigms and principles 3059-3087, 2001
90 "Hedgehog signaling from the ZLI regulatesdiencephalic regional identity" 1242-1249, 2004
91 "Hedgehog regulates cellgrowth and proliferation by inducing Cyclin D and CyclinE" 299-417 304, 2002
92 "Hedgehog inducesopposite changes in turnover and subcellular localization ofpatched and smoothened" 521-531, 2000
93 "Hedgehog elicits signal transduction bymeans of a large complex containing the kinesin-relatedprotein costal2" 225-234, 1997
94 "Hedgehog and PI-3kinase signaling converge on Nmyc1 to promote cell cycleprogression in cerebellar neuronal precursors" 217-228, 2004
95 "Graded interference with FGF signalling revealsits dorsoventral asymmetry at the mid-hindbrainboundary" 5659-126 5667, 1999
96 "Gli3 is requiredfor Emx gene expression during dorsal telencephalondevelopment" 3561-126 3571, 1999
97 "Gli2 isrequired for induction of floor plate and adjacent cells butnot most ventral neurons in the mouse central nervoussystem" 2759-125 2770, 1998
98 "Gli1 can rescue the in vivo function of Gli2" 5161-128 5172, 2001
99 "Genetic dissection of theDrosophila Cubitus interruptus signaling complex" 411-236 420, 2001
100 "Gata2 specifies serotonergic neurons downstream of sonichedgehog" 1165-131 1173, 2004
101 "Functionfor Hedgehog genes in zebrafish retinal development" 238-220 252, 2000
102 "Floor plate and motor neuron induction bydifferent concentrations of the amino-terminal cleavageproduct of sonic hedgehog autoproteolysis" 445-455, 1995
103 "FGF and Shh signals control dopaminergic and serotonergiccell fate in the anterior neural plate" 755-766, 1998
104 "Extraretinal and retinal hedgehog signalingsequentially regulate retinal differentiation in zebrafish" 349-363, 2003
105 "Extensivephosphorylation of Smoothened in Hedgehog pathwayactivation" 17900-17907, 2004
106 "Expressionof three mouse homologs of the Drosophila segmentpolarity gene cubitus interruptus inectoderm- and mesoderm-derived tissues suggests multipleroles during postimplantation development" 402-2 3 413, 1994
107 "Expressionof the vertebrate Gli proteins in Drosophila reveals a distributionof activator and repressor activities" 4293-4301, 2000
108 "Expression of the mouse Gli andPtc genes is adjacent to embryonic sources of hedgehogsignals suggesting a conservation of pathways betweenflies and mice" 121-135, 1997
109 "Expression of Sonic hedgehog and itsputative role as a precursor cell mitogen in the developingmouse retina" 363-124 371, 1997
110 "Dual pathways for induction of winglessexpression by protein kinase A and Hedgehog inDrosophila embryos" 2250-2258, 1997
111 "Drosophila Costal1mutations are alleles of protein kinase A that modulatehedgehog signaling" 7837-167 96, 2004
112 "Dorsoventral patterning of thetelencephalon is disrupted in the mouse mutant extra-toes" 254-265, 2000
113 "Dorsoventral patterning is established in the telencephalonof mutants lacking both Gli3 and Hedgehog signaling" gaia (gaia): 4963-129 4974, 2002
114 "Distinctsites of origin of oligodendrocytes and somatic motoneuronsin the chick spinal cord 2-expressing progenitors by a Shh-dependentmechanism" Danesin C 1369-128 1379, 2001
115 "Distinctand collaborative roles of Drosophila EXT family proteinsin morphogen signalling and gradient formation" 1563-1575, 2004
116 "Distinct and regulated activities of humanGli proteins in Drosophila" 1319-1322, 1999
117 "Diminished Sonic hedgehog signaling and lack of floorplate differentiation in Gli2 mutant mice" 2533-2543, 1998
118 "Developmentof normal retinal organization depends on Sonichedgehog signaling from ganglion cells" 831-832, 2002
119 "Determination of neuroepithelial cellfate induction of the oligodendrocyte lineage by ventralmidline cells and sonic hedgehog" 30-42, 1996
120 "Cooperation of BMP7 and SHH in the inductionof forebrain ventral midline cells by prechordal mesoderm" 257-269, 1997
121 "Control of oligodendrocyte differentiation by theNkx2" 2723-2733, 2001
122 "Control of neuronal precursor proliferationin the cerebellum by Sonic Hedgehog" 103-22 114, 1999
123 "Conservation of the hedgehog/patched signaling pathwayfrom flies to mice induction of a mouse patched gene byHedgehog" 301-312, 1996
124 "Common developmental requirement for Olig functionindicates a motor neuron/oligodendrocyte connection" 75-86, 2002
125 "Cloning andcharacterization of the segment polarity gene cubitus interruptusDominant of Drosophila" 1053-1067, 1990
126 "Cholesterol modification ofhedgehog signaling proteins in animal development" 255-274 259, 1996
127 "Characterization of Suppressor of fused a complete suppressorof the fused segment polarity gene of Drosophilamelanogaster" 725-132 736, 1992
128 "Bmp2 antagonizessonic hedgehog-mediated proliferation of cerebellar granuleneurones through Smad5 signalling" 3159-131 3168, 2004
129 "BMP-7 influences pattern and growth ofthe developing hindbrain of mouse embryos" 1-12, 1997
130 "Autoproteolysis in hedgehog protein biogenesis" 1528-1537, 1994
131 "All mouse ventral spinal cord patterningby hedgehog is Gli dependent and involves an activatorfunction of Gli3" 103-115, 2004
132 "Activity-dependent internalizationof smoothened mediated by beta-arrestin 2 and GRK2" 2257-306 2260, 2004b
133 "Abnormalities of the vitreoretinal interface caused by dysregulatedHedgehog signaling during retinal development" 3269-3276, 2003
134 "A role of PDGFRα in basal cell carcinomaproliferation" 9255-9259, 2001
135 "A role for Sonic hedgehog in axon-toastrocytesignalling in the rodent optic nerve" 2901-2909, 1999
136 "A putative serine/threonine protein kinase encoded by the segment-polarityfused gene of Drosophila" 87-347 89, 1990
137 "A novel function for Hedgehog signalling inretinal pigment epithelium differentiation" 1565-1577, 2003
138 "A homeodomain proteincode specifies progenitor cell identity and neuronalfate in the ventral neural tube" 435-445, 2000
139 "A functionally conservedhomolog of the Drosophila segment polarity gene hh isexpressed in tissues with polarizing activity in zebrafishembryos" 1431-1444, 1993
140 "A freely diffusible form of Sonic hedgehog mediateslong-range signalling" 716-411 720, 2001
141 "A direct requirementfor Hedgehog signaling for normal specificationof all ventral progenitor domains in the presumptive mammalianspinal cord" 2849-2864, 2002
142 "A binding site for Gliproteins is essential for HNF-3beta floor plate enhanceractivity in transgenics and can respond to Shh in vitro" 1313-124 1322, 1997