Dexamethasone, 6α-methylprednisolone 및 retinoic acid가 쥐 교종세포인 C6의 세포성장 및 형태에 미치는 영향 = The Effects of Dexamethasone, 6α-Methylprednisolone, and Retinoic Acid on the Growth and Morphology of a Rat Glioma Cell Line, C6

다국어 초록 (Multilingual Abstract)

Glucocorticoids, dexamethasone, 6α-methylprednisolone are routinely administered to brain tumor patients to reduce peritumoral edema before surgical removal of the tumor. In addition, the glucocorticoids can inhibit growth several cell lines. Retinoic acid, a derivative of vitamin A is also known to inhibit growth of several cell lines. Sometimes inhibition of growth accompany morphological changes.
In the present study, we compared the effects of dexamethasone, 6α-methylprednisolone, and retinoic acid on the growth and on the morphology of a rat glioma cell line, C6. We found that all of them can maximally inhibit the growth of C6 by approximately 30%(p<0.0025) in the presence of 10μM of either dexamethasone, 6α-methylprednisolone or retinoic acid under our experimental conditions. However, only retinoic acid could induce the morphological changes were observed both at the subconfluent and confluent cell population. When mixture of 10μM of dexamethasone and 10μM of retinoic acid was added, no further increase in the inhibition of growth was observed compared with the inhibition obtained by adding 10μM of dexamethasone only.
The results suggest that the glucocorticoids might have effects of growth inhibition of the glial tumor in vivo.