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      양성 갑상선 낭성 결절에서 에탄올 경화 요법의 결과 = The Results of Ethanol Sclerotherapy on Benign Thyroid Cystic Nodule

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      https://www.riss.kr/link?id=A104783572

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      다국어 초록 (Multilingual Abstract)

      Objectives:Ethanol injection under ultrasound guidance has been proposed as an alternative to surgery in the treatment of benign thyroid cysts. So we evaluated efficacy and safety of ultrasonography guided ethanol sclerotherapy for cystic thyroid nodules with analyzing results retrospectively. Methods:Between May 2010 and Jun 2012, 18 cystic thyroid nodule patients (19 cysts) were treated with ethanol ablation. We evaluated the treatment outcomes with the change of volume reduction and the improvement of symptomatic and cosmetic complains and complications. Results:Initial mean cystic nodule volume was 8.5 mL (range, 0.4-31 mL) and mean volume after ablation 1 week was 5.7 mL (range, 0.02-21 mL) in ultrasonography (p=0.154). Each of the mean volume at 1 month and 6 months after treatment was 2.9 mL (0-13 mL, p=0.002) and 0.8 mL (0-5.9 mL, p=0.000). The mean volume reduction rate was 90% (50-100%). Mean symptoms and cosmetic grading scores improved from 5 to 1.7 and from 3.5 to 1.5 (p=0.000). No significant complications were observed during the follow up. Conclusions:Percutaneous ethanol injection may prove a safe and effective tool for the therapy of the benign thyroid cysts.
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      Objectives:Ethanol injection under ultrasound guidance has been proposed as an alternative to surgery in the treatment of benign thyroid cysts. So we evaluated efficacy and safety of ultrasonography guided ethanol sclerotherapy for cystic thyroid no...

      Objectives:Ethanol injection under ultrasound guidance has been proposed as an alternative to surgery in the treatment of benign thyroid cysts. So we evaluated efficacy and safety of ultrasonography guided ethanol sclerotherapy for cystic thyroid nodules with analyzing results retrospectively. Methods:Between May 2010 and Jun 2012, 18 cystic thyroid nodule patients (19 cysts) were treated with ethanol ablation. We evaluated the treatment outcomes with the change of volume reduction and the improvement of symptomatic and cosmetic complains and complications. Results:Initial mean cystic nodule volume was 8.5 mL (range, 0.4-31 mL) and mean volume after ablation 1 week was 5.7 mL (range, 0.02-21 mL) in ultrasonography (p=0.154). Each of the mean volume at 1 month and 6 months after treatment was 2.9 mL (0-13 mL, p=0.002) and 0.8 mL (0-5.9 mL, p=0.000). The mean volume reduction rate was 90% (50-100%). Mean symptoms and cosmetic grading scores improved from 5 to 1.7 and from 3.5 to 1.5 (p=0.000). No significant complications were observed during the follow up. Conclusions:Percutaneous ethanol injection may prove a safe and effective tool for the therapy of the benign thyroid cysts.

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      참고문헌 (Reference)

      1 홍재형, "양성 두경부 낭종성 병변에 대한 경화치료의 효과 분석" 대한이비인후과학회 부산,울산,경남 지부회 20 (20): 40-48, 2009

      2 김세헌, "단일 갑상선 결절의 평가와 진단" 대한이비인후과학회 45 (45): 1033-1038, 2002

      3 이가희, "갑상선결절의 진단 및 치료" 대한의사협회 54 (54): 629-636, 2011

      4 여창기, "갑상선 양성결절의 고주파 치료" 대한이비인후과학회 57 (57): 151-154, 2014

      5 김윤정, "갑상선 양성 결절에서 갑상선 호르몬 억제요법의 효과" 대한이비인후과학회 52 (52): 674-678, 2009

      6 Cho YS, "Sonographically guided ethanol sclerotherapy for benign thyroid cysts: results in 22 patients" 174 (174): 213-216, 2000

      7 Kim YS, "Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience" 16 (16): 361-367, 2006

      8 Hooft L, "Practice, efficacy, and costs of thyroid nodule evaluation: a retrospective study in a Dutch university hospital" 14 (14): 287-293, 2004

      9 Zingrillo M, "Percutaneous ethanol injection may be a definitive treatment for symptomatic thyroid cystic nodules not treatable by surgery: five-year f ollow-up study" 9 (9): 763-767, 1999

      10 Livraghi T, "Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients" 69 (69): 925-929, 1992

      1 홍재형, "양성 두경부 낭종성 병변에 대한 경화치료의 효과 분석" 대한이비인후과학회 부산,울산,경남 지부회 20 (20): 40-48, 2009

      2 김세헌, "단일 갑상선 결절의 평가와 진단" 대한이비인후과학회 45 (45): 1033-1038, 2002

      3 이가희, "갑상선결절의 진단 및 치료" 대한의사협회 54 (54): 629-636, 2011

      4 여창기, "갑상선 양성결절의 고주파 치료" 대한이비인후과학회 57 (57): 151-154, 2014

      5 김윤정, "갑상선 양성 결절에서 갑상선 호르몬 억제요법의 효과" 대한이비인후과학회 52 (52): 674-678, 2009

      6 Cho YS, "Sonographically guided ethanol sclerotherapy for benign thyroid cysts: results in 22 patients" 174 (174): 213-216, 2000

      7 Kim YS, "Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience" 16 (16): 361-367, 2006

      8 Hooft L, "Practice, efficacy, and costs of thyroid nodule evaluation: a retrospective study in a Dutch university hospital" 14 (14): 287-293, 2004

      9 Zingrillo M, "Percutaneous ethanol injection may be a definitive treatment for symptomatic thyroid cystic nodules not treatable by surgery: five-year f ollow-up study" 9 (9): 763-767, 1999

      10 Livraghi T, "Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients" 69 (69): 925-929, 1992

      11 Sung JY, "Optimum first-line treatment technique for benign cystic thyroid nodules:ethanol ablation or radiofrequency ablation?" 196 (196): 210-214, 2011

      12 Westermark K, "Location of epidermal growth factor receptors on porcine thyroid follicle cells and receptor regulation by thyrotropin" 118 (118): 1040-1046, 1986

      13 Jang SW, "How to manage the patients with unsatisfactory results after ethanol ablation for thyroid nodules: role of radiofrequency ablation" 81 (81): 905-910, 2012

      14 Larijani B, "Evaluation of suppressive therapy for cold thyroid nodules with levothyroxine: double-blind placebo-controlled clinical trial" 5 (5): 251-256, 1999

      15 Lee DK, "Efficacy of ethanol ablation for thyroglossal duct cyst" 124 (124): 62-67, 2015

      16 Kim YJ, "Cystic versus predominantly cystic thyroid nodules:efficacy of ethanol ablation and analysis of related factors" 22 (22): 1573-1578, 2012

      17 Kalra N, "Comparison of sonographically guided percutaneous sodium tetradecyl sulfate injection with ethanol injection in the treatment of benign nonfunctioning thyroid nodules" 25 (25): 1218-1224, 2014

      18 Ha EJ, "Clinical significance of vagus nerve variation in radiofrequency ablation of thyroid nodules" 21 (21): 2151-2157, 2011

      19 Hegedüs L., "Clinical practice. The thyroid nodule" 351 (351): 1764-1771, 2004

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