Comparing the stability of retinol in liposomes with cholesterol, β-sitosterol, and stigmasterol

다국어 초록 (Multilingual Abstract)

In this study, cholesterol (CH), b-sitosterol (SI),and stigmasterol (ST) were explored to improve the stabilityof retinol in the liposome bilayer. Retinol wasincorporated into liposomes composed of soybean-derivedL-a-phosphatidylcholine (PC) and 10% sterol (w/w), whichwere prepared as multilamellar vesicles. Under all conditions,the efficiency of retinol incorporation into liposomeswas higher than 99%, and the average particle size ofliposomes was similar to that of PC alone. Liposomes werestored at 4 and 25 C, with and without light, respectively,for 10 days. It was found that during the storage, CH andSI were effective in stabilizing the retinol in liposomes.
These results indicate that an appropriate phytosterol couldimprove the stability of retinol in liposomes.

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