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    Clinical experience of hemoperfusion treatment in children with paraquat poisoning

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    https://www.riss.kr/link?id=A108169647

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    다국어 초록 (Multilingual Abstract) kakao i 다국어 번역

    Paraquat is a fatal, rapid-acting, nonselective herbicide. Despite the restriction of production and sales of the herbicide in Korea since 2012, already purchased paraquat can incur poisoning. This article describes a 25-month-old boy who accidentally ingested old paraquat on a rural road. After initial decontamination at 2 outside hospitals, he was transferred to the intensive care unit. Given the urine drug concentration of 20,000 ng/mL 2 hours after the intoxication, he received charcoal hemoperfusion and continuous venovenous hemofiltration to enhance the excretion of the herbicide. In 36 hours after intoxication, it was not detected in the urine. The boy was discharged uneventfully on day 8. This case highlights the importance of hemoperfusion in paraquat poisoning.
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    Paraquat is a fatal, rapid-acting, nonselective herbicide. Despite the restriction of production and sales of the herbicide in Korea since 2012, already purchased paraquat can incur poisoning. This article describes a 25-month-old boy who accidentally...

    Paraquat is a fatal, rapid-acting, nonselective herbicide. Despite the restriction of production and sales of the herbicide in Korea since 2012, already purchased paraquat can incur poisoning. This article describes a 25-month-old boy who accidentally ingested old paraquat on a rural road. After initial decontamination at 2 outside hospitals, he was transferred to the intensive care unit. Given the urine drug concentration of 20,000 ng/mL 2 hours after the intoxication, he received charcoal hemoperfusion and continuous venovenous hemofiltration to enhance the excretion of the herbicide. In 36 hours after intoxication, it was not detected in the urine. The boy was discharged uneventfully on day 8. This case highlights the importance of hemoperfusion in paraquat poisoning.

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    참고문헌 (Reference)

    1 Li C, "Treatment outcome of combined continuous venovenous hemofiltration and hemoperfusion in acute paraquat poisoning : a prospective controlled trial" 46 : 100-107, 2018

    2 Houze P, "Toxicokinetics of paraquat in humans" 9 : 5-12, 1990

    3 Scherrmann JM, "Prognostic value of plasma and urine paraquat concentration" 6 : 91-93, 1987

    4 Senarathna L, "Prediction of outcome after paraquat poisoning by measurement of the plasma paraquat concentration" 102 : 251-259, 2009

    5 최원석 ; 정은행 ; 서정연 ; 전경홍 ; 강명수 ; 김향, "Paraquat 중독 환자에서 혈액관류의 유용성" 대한내과학회 80 (80): 308-316, 2011

    6 홍용천 ; 류현호 ; 이병국 ; 문정미 ; 전병조, "Paraquat 중독 환자에서 내원시 측정된 혈중 Paraquat 농도와 Severity Index of Paraquat Poisoning (SIPP)의 의의" 대한응급의학회 19 (19): 513-520, 2008

    7 Hsieh YW, "Paraquat poisoning in pediatric patients" 29 : 487-491, 2013

    8 Qiu L, "Paraquat poisoning in children : a 5-year review" 37 : e846-e849, 2021

    9 Proudfoot AT, "Paraquat poisoning : significance of plasma-paraquat concentrations" 314 : 330-332, 1979

    10 Jones GM, "Mechanisms of toxicity, clinical features, and management of diquat poisoning : a review" 38 : 123-128, 2000

    1 Li C, "Treatment outcome of combined continuous venovenous hemofiltration and hemoperfusion in acute paraquat poisoning : a prospective controlled trial" 46 : 100-107, 2018

    2 Houze P, "Toxicokinetics of paraquat in humans" 9 : 5-12, 1990

    3 Scherrmann JM, "Prognostic value of plasma and urine paraquat concentration" 6 : 91-93, 1987

    4 Senarathna L, "Prediction of outcome after paraquat poisoning by measurement of the plasma paraquat concentration" 102 : 251-259, 2009

    5 최원석 ; 정은행 ; 서정연 ; 전경홍 ; 강명수 ; 김향, "Paraquat 중독 환자에서 혈액관류의 유용성" 대한내과학회 80 (80): 308-316, 2011

    6 홍용천 ; 류현호 ; 이병국 ; 문정미 ; 전병조, "Paraquat 중독 환자에서 내원시 측정된 혈중 Paraquat 농도와 Severity Index of Paraquat Poisoning (SIPP)의 의의" 대한응급의학회 19 (19): 513-520, 2008

    7 Hsieh YW, "Paraquat poisoning in pediatric patients" 29 : 487-491, 2013

    8 Qiu L, "Paraquat poisoning in children : a 5-year review" 37 : e846-e849, 2021

    9 Proudfoot AT, "Paraquat poisoning : significance of plasma-paraquat concentrations" 314 : 330-332, 1979

    10 Jones GM, "Mechanisms of toxicity, clinical features, and management of diquat poisoning : a review" 38 : 123-128, 2000

    11 Wang Y, "Effects of hemoperfusion and continuous renal replacement therapy on patient survival following paraquat poisoning" 12 : e0181207-, 2017

    12 Hsu CW, "Early hemoperfusion may improve survival of severely paraquat-poisoned patients" 7 : e48397-, 2012

    13 Wu WP, "Addition of immunosuppressive treatment to hemoperfusion is associated with improved survival after paraquat poisoning : a nationwide study" 9 : e87568-, 2014

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