인터루킨-12/23 (Interleukin-12/23) 억제제로 치료 중인 건선 환자에서 발생한 전신형 고리육아종 1예 = A Case of Generalized Granuloma Annulare Development in a Psoriasis Patient Treated with Interleukin-12/23 Blockers

다국어 초록 (Multilingual Abstract)

Granuloma annulare is a relatively common inflammatory skin disease. The etiology is unknown; however, drugshave been considered as one of the predisposing conditions, and a few cases of granuloma annulare related to biologics have been recently reported. A 48-year-old man with a 25-year history of psoriasis visited our dermatologicalclinic. Ustekinumab was administered for the treatment of psoriasis. After 5 years of ustekinumab therapy, erythematous papules with an annular distribution appeared on his trunk and extremities. Skin biopsy supported thediagnosis of generalized granuloma annulare, and the patient continued to receive ustekinumab with oral methotrexate, cyclosporine, and steroids for 9 months. However, as the skin lesions aggravated, oral steroid treatment wascontinued, and secukinumab was administered instead of ustekinumab. The skin lesions improved and remainedstable with the intermittent administration of oral steroids thereafter.