Case Report of Pediatric Gastroenteritis Due to CTX-M-15 Extended-Spectrum β-Lactamase-Producing Salmonella enterica Serotype Enteritidis

다국어 초록 (Multilingual Abstract)

A clinical isolate of Salmonella enterica serotype Enteritidis in Korea was found to produce the extended-spectrum β-lactamase CTX-M-15. The isolate was recovered in 2008 from the stool of a 3-yr-old boy with gastroenteritis. This isolate was found to be resistant to multiple drugs, including ampicillin, piperacillin, cefotaxime, ceftazidime, cefepime, and aztreonam. The resistance to cefotaxime was transferred by conjugation to recipient Escherichia coli J53. The patient was eventually successfully treated with trimethoprim-sulfamethoxazole. This is the first report of the blaCTX-M-15 gene in S. enterica serotype Enteritidis in Korea.

참고문헌 (Reference)

1 Batchelor M, "bla (CTX-M) genes in clinical Salmonella isolates recovered from humans in England and Wales from 1992 to 2003" 49 : 1319-1322, 2005

2 Stephen JM, "Salmonella bloodstream infections: report from the SENTRY antimicrobial surveillance program (1997-2001)" 22 : 395-405, 2003

3 Guerrant RL, "Practice guidelines for the management of infectious diarrhea" 32 : 331-351, 2001

4 Karim A, "Plasmid-mediated extended-spectrum β-lactamase (CTX-M-3 like) from India and gene association with insertion sequence ISEcp1" 201 : 237-241, 2001

5 Di Conza J, "Novel class 1 integron (InS21) carrying blaCTX-M-2 in Salmonella enterica serovar Infantis" 46 : 2257-2261, 2000

6 Yong D, "Nosocomial outbreak of pediatric gastroenteritis caused by CTX-M-14-type extended-spectrum β-lactamase-producing strains of Salmonella enterica serovar London" 43 : 3519-3521, 2005

7 Edelstein M, "Multiple outbreaks of nosocomial salmonellosis in Russia and Belarus caused by a single clone of Salmonella enterica serovar Typhimurium producing an extended-spectrum β-lactamase" 48 : 2808-2815, 2004

8 Sambrook J, "Molecular cloning: a laboratory manual. 2nd ed" Cold Spring Harbor Laboratory Press 1989

9 Bonnet R, "Growing group of extended-spectrum β-lactamases: the CTX-M enzymes" 48 : 1-14, 2004

10 Morris D, "First report of extended-spectrum β-lactamase-producing Salmonella enterica isolates in Ireland" 50 : 1608-1609, 2006

11 Touati A, "First report of CTX-M-15 in Salmonella enterica serotype Kedougou recovered from an Algerian hospital" 27 : 479-480, 2008

12 Kim HH, "Epidemiological characteristics of Salmonella strains isolated recently in Korea" 34 : 595-598, 1999

13 Rotimi VO, "Emergence of CTX-M-15 type extended-spectrum β-lactamase-producing Salmonella spp. in Kuwait and the United Arab Emirates" 57 : 881-886, 2008

14 Lee K, "Diversity of TEM-52 extended-spectrum β-lactamase-producing non-typhoidal Salmonella isolates in Korea" 52 : 493-496, 2003

15 Romero L, "Characterization of the first CTX-M-14-producing Salmonella enterica serotype Enteritidis isolate" 53 : 1113-1114, 2004

16 Usha G, "Characterization of extended-spectrum β-lactamases in Salmonella spp. at a tertiary hospital in Durban, South Africa" 62 : 86-91, 2008

17 Weill FX, "Characterization of extended-spectrum β-lactamase (CTX-M-15)-producing strains of Salmonella enterica isolated in France and Senegal" 238 : 353-358, 2004

18 Baraniak A, "Ceftazidime-hydrolysing CTX-M-15 extended-spectrum β-lactamase (ESBL) in Poland" 50 : 393-396, 2002

19 Tzouvelekis LS, "CTX-M-type β-lactamases: an emerging group of extended-spectrum enzymes" 14 : 137-142, 2000

20 Su LH, "Antimicrobial resistance in nontyphoid Salmonella serotypes: a global challenge" 39 : 546-551, 2004