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Bone marrow mesenchymal stem cells (MSCs) have the potential to ameliorate neurologic deficits and promote brain repair following stroke. To examine how polyamines (PAs) level change in rats brain following intravenous human MSC (hMSC) transplantation...
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RISS 인기검색어
Analysis of free polyamine metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats
한글로보기https://www.riss.kr/link?id=G3806354
- 저자
- 발행기관
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발행연도
2009년
-
작성언어
English
-
주제어
뇌경색 ; 중간엽줄기세포 ; 폴리아민 ; Brain ischemia ; Mesenchymal stem cell ; Polyamine
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자료형태
한국연구재단(NRF)
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
Bone marrow mesenchymal stem cells (MSCs) have the potential to ameliorate neurologic deficits and promote brain repair following stroke. To examine how polyamines (PAs) level change in rats brain following intravenous human MSC (hMSC) transplantation into rats that had undergone transient middle cerebral artery occlusion (MCAo), we investigated changes in free PAs following rats were subjected to 2-hours MCAo, followed by intravenous transplantation of hMSC or phosphate-buffered saline (PBS) at one day after MCAo. All rats were sacrificed 5 days after MCAo. Metabolic profiling of free PAs levels was investigated in brain from control rats (n=10), PBS-treated MCAo rats (n=7), and hMSC-treated MCAo rats (MCAo + hMSC, n=7). The levels of PAs in brain samples of the MCAo and MCAo + hMSC groups were significantly different from those of the control group. The percentage composition of cadaverine and spermidine in brain tissues of the MCAo + hMSC group were significantly reduced compared to those in the PBS-treated MCAo group. Thus, our metabolomic approach might be useful for discrimination and biochemical monitoring of therapeutic effects in rat MCAo model after transplantation with hMSC.
Bone marrow mesenchymal stem cells (MSCs) have the potential to ameliorate neurologic deficits and promote brain repair following stroke. To examine how polyamines (PAs) level change in rats brain following intravenous human MSC (hMSC) transplantation into rats that had undergone transient middle cerebral artery occlusion (MCAo), we investigated changes in free PAs following rats were subjected to 2-hours MCAo, followed by intravenous transplantation of hMSC or phosphate-buffered saline (PBS) at one day after MCAo. All rats were sacrificed 5 days after MCAo. Metabolic profiling of free PAs levels was investigated in brain from control rats (n=10), PBS-treated MCAo rats (n=7), and hMSC-treated MCAo rats (MCAo + hMSC, n=7). The levels of PAs in brain samples of the MCAo and MCAo + hMSC groups were significantly different from those of the control group. The percentage composition of cadaverine and spermidine in brain tissues of the MCAo + hMSC group were significantly reduced compared to those in the PBS-treated MCAo group. Thus, our metabolomic approach might be useful for discrimination and biochemical monitoring of therapeutic effects in rat MCAo model after transplantation with hMSC.
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