고령여성의 ACE 유전자 다형성과 골밀도 및 골강도, 기초체력과의 관련성 = Association of ACE Polymrophism with BMD, Bone Strength, and Basal Physical Fitness in Elderly Women

다국어 초록 (Multilingual Abstract)

This study was designed to clarify an association of ACE polymrophism with bone mineral density(BMD), bone strength, and basal physical fitness in elderly women. We determined the ACE polymorphism using a polymerase chain reaction(PCR), in a DNA sample of 64 elderly women aged 75.4 ± 8.5 yrs. The genetic subtype was characterized by the presence(insertion, I allele) or absence(deletion, D allele) of a 287 base pair fragment and then BMD, bone strength and basal physical fitness were compared among genotypes. A densitometric studies on lumbar spine and femur and analyses of ultrasonic wave in calcaneus were performed. For the genotype distribution, 34.4%(n = 22) were II genotype, 42.2%(n = 27) were ID genotype and 23.4%(n = 15) were DD genotype, respectively. The lumbar vertebra 1 (L1) BMD of II genotype was significantly 19.5% higher than that of DD genotype(p < .05), and L4 BMD of II genotype was also significantly 18.5% higher than that of DD genotype(p < .05). Resting heart rate of II genotype was significantly lower than that of ID genotype(p < .05), and no differences were observed in basal physical fitness. Although a moderate negative correlation was found between age and femur BMD, calcaneus bone strength(p < .05), a positive correlation was found between muscle mass and lumbar and femur BMD(p < .05, p < .01). These results suggest that ACE gene polymorphism might be used as a one of genetic determinants of bone mass in elderly women.

목차 (Table of Contents)

• Abstract
• 1. 서론
• 2. 연구방법 및 측정항목
• 3. 결과
• 4. 고찰
• 5. 결론
• 인용문헌

참고문헌 (Reference)

1 최석준, "복합훈련이 안지오텐신 전환효소 유전자의 다형성에 따라 체력에 미치는 관련성" 국민체육진흥공단 체육과학연구원 13 (13): 1-16, 2002

2 우상구, "고등학교 운동선수와 일반학생들을 대상으로 안지오텐신 전환효소 유전자다형의 상대적 빈도" 대한스포츠의학회 23 (23): 71-77, 2005

3 Riggs, B. L., "Tibolone as an alternative to estrogen for the prevention of postmenopausal osteoporosis in selected postmenopausal women" 81 (81): 2417-2418, 1996

4 Canalis, E., "The hormonal and local regulation of bone formation" 4 : 62-77, 1983

5 Collins M., "The ACE gene and endurance performance during the South African Ironman Triathlons" 36 (36): 1314-1320, 2004

6 Cammarata, P. R., "Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cells" 78 (78): 861-871, 2004

7 Kaneko M., "Standard radial bone mineral density and physical factors in ordinary Japanese women" 18 (18): 31-35, 2000

8 Malik, F. S., "Renin-angiotensin system : genes to bedside" 134 (134): 514-526, 1997

9 Zhao L., "Relationship of obesity with osteoporosis" 92 (92): 1640-1646, 2007

10 Hsu Y. H., "Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in chinese men and women" 83 (83): 146-154, 2006

11 Kyung N. H., "Relation of Angiotensin Converting Enzyme(ACE)Gene Polymorphism to Insulin Sensitivity and Carotid Atherosclerosis in Female Nondiabetic Offspring of NIDDM Patients" 23 (23): 831-842, 1999

12 Lee W. S., "Prevalence of Osteoporosis in Korean Women" 9 (9): 339-346, 2003

13 Morrison N. A., "Prediction of bone density form vitamin D receptor alleles" 367 : 284-287, 1994

14 Langdahl B. L., "Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures" 17 : 1245-1255, 2002

15 Williams, A. G., "Physiology : The ACE gene and muscle performance" 403 : 614-, 2000

16 Christenson E. S., "Osteoporosis management in post-menopausal women" 64 (64): 181-194, 2012

17 Rankinen, T., "No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status" 88 (88): 1571-1575, 2000

18 Heaney, R. P., "Menopausal changes in bone remodeling" 92 (92): 964-970, 1978

19 Osono E., "Insertion/deletion polymorphism in intron 16 of the ACE gene and left ventricular hypertrophy in patients with end-stage renal disease" 32 (32): 725-230, 1998

20 Jones A., "Human performance: a role for the ACE genotype?" 30 (30): 184-190, 2002

21 Montgomery, H. E., "Human gene for physical performance" 392 (392): 221-222, 1998

22 Alvarez R., "Genetic variation in the renin-angiotensin system and athletic performance" 82 (82): 117-120, 2000

23 Arden, N. K., "Genetic influences on muscle strength, lean body mass, and bone mineral density : a twin study" 12 (12): 2076-2081, 1997

24 Thiel, B., "Genes for essential hypertension: Hype, Help, or Hope?" 2 : 187-193, 2000

25 Tarquini B., "Evidence for bone mass and body fat distribution relationship in postmenopausal obese women" 24 (24): 15-21, 1997

26 Woods, D. R., "Endurance enhancement related to the human angiotensin I-converting enzyme I-D polymorphism is not due to differences in the cardiorespiratory response to training" 86 : 240-244, 2002

27 Yang C. Y., "Effects of habitual chitosan intake on bone mass, bone-related metabolic markers and duodenum CaBP D9K mRNA in ovariectomized SHRSP rats" 48 (48): 371-378, 2002

28 Kurabayashi, T., "Effect of vitamin D receptor and estrogen receptor gene polymorphism on the relationship between dietary calcium and bone mineral density in Japanese women" 22 (22): 139-147, 2004

29 Lamparter, S., "Effect of angiotensin II on bone cells in vitro" 175 : 89-98, 1998

30 Mullersman J. E., "Characterization of two novel polymorphisms at the human parathyroid hormone gene locus" 88 : 589-592, 1992

31 Smathers A. M., "Bone density comparisons in male competitive road cyclists and untrained controls" 41 (41): 290-296, 2009

32 Wulff Helge E., "BMD in elite female triathletes is related to isokinetic peak torque without any association to sex hormone concentrations" 52 (52): 489-500, 2012

33 Yamada S., "Associations between physical activity, peripheral atherosclerosis and bone status in healthy Japanese women" 188 (188): 196-202, 2006

34 Tsukamoto K., "Association of radial bone mineral density with CA repeat polymorphism at the interleukin 6 locus in postmenopausal Japanese women" 44 : 148-151, 1999

35 Kobayashi, S., "Association of bone mineral density with polymorphism of the estrogen receptor gene" 11 (11): 306-311, 1996

36 Kanazawa H., "Association between the angiotensin-converting enzyme gene polymorphisms and tissue oxygenation during exercise in patients with COPD" 121 (121): 697-701, 2002

37 Altun B., "Association between activated renin angiotensin system and bone formation in hemodialysis patients: is the bone mass genetically determined by ACE gene polymorphism?" 26 (26): 425-431, 2004

38 Karjalainen J., "Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes" 34 (34): 494-499, 1999

39 Hiruma, Y., "Angiotensin II stimulates the proliferation of osteoblast-rich populations of cells from rat calvaria" 230 : 176-178, 1997

40 Hatton, R., "Angiotensin II generated from angiotensin I by bone cells and stimulates osteoclastic bone resorption in vitro" 152 : 5-10, 1997

41 Fujisawa T., "Angiotensin I-converting enzyme gene polymorphism is associated with myocardial infarction, but not with retinopathy or nephropathy, in NIDDM" 18 (18): 983-985, 1995

42 Rigat B., "An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels" 86 (86): 1343-1346, 1990

43 Davis N. C., "Age stereotypes in middle-aged through old-old adults" 70 (70): 199-212, 2010

44 김창선, "ACE 유전자 다형과 대학생의 기초체력, 골강도와의 관련성" 한국체육과학회 15 (15): 665-674, 2006

45 통계청, "2011 고령자통계"