Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer

다국어 초록 (Multilingual Abstract)

Cancer is the most dreaded disease in human and also major health problem worldwide. Despite its high occurrence, theexact molecular mechanisms of the development and progression are not fully understood. The existing cancer therapybased on allopathic medicine is expensive, exhibits side effects; and may also alter the normal functioning of genes. Thus, anon-toxic and effective mode of treatment is needed to control cancer development and progression. Some medicinal plantsoffer a safe, effective and affordable remedy to control the cancer progression. Nimbolide, a limnoid derived from the neem(Azadirachta indica) leaves and flowers of neem, is widely used in traditional medical practices for treating various humandiseases. Nimbolide exhibits several pharmacological effects among which its anticancer activity is the most promising. Theprevious studies carried out over the decades have shown that nimbolide inhibits cell proliferation and metastasis of cancercells. This review highlights the current knowledge on the molecular targets that contribute to the observed anticanceractivity of nimbolide related to induction of apoptosis and cell cycle arrest; and inhibition of signaling pathways related tocancer progression.

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