Synthesis of the Densely Functionalized Carbocyclic Moiety of Tetrodotoxin by Radical Cyclization of an Anhydro Sugar Precursor = Anhydro Sugar 전구체의 Radical Cyclization을 통한 Tetrodotoxin의 다작용기화된 Carbocyclic 부분의 합성

국문 초록 (Abstract)

Tetrodotoxin의 핵심은 다작용기화된 carbocycle이며 고리화된 pyranose가 중요한 중간물질로 사용될 수 있다. Carbocyclic ring은 1,6-anhydromannose로부터 만들어진 실릴화 중간체(17b)에 질소를 조기에 도입시킴으로써 합성할 수 있다. 이 논문에서는 고리화된 pyranose에 관계된 합성변환을 다루었다.

다국어 초록 (Multilingual Abstract)

The core of tetrodotoxin is a densely functionalized carbocycle. An annulated pyranose can be envisaged as a important intermediate. The Carbocyclic ring can be synthesized by early introduction of nitrogen to silylated intermediate(17b) which was prepared from 1,6-anhydromannose. A novel procedure is described for synthetic transformations related to the annulated pyranoside.

목차 (Table of Contents)

• Ⅰ.Introduction
• Ⅱ.Experimental
• Ⅲ.Results and Disscusion
• Ⅳ.Conclusion