난용성 약물인 Isoflavone계 화합물을 함유한 하이드로콜로이드 패치의 물리화학적 특성

다국어 초록 (Multilingual Abstract)

Genistein and daidzein, phytoestrogens belonging to the isoflavone class, have a role in the treatment and prevention of various cancers, antioxidant and anti-inflammation activity. However, it is difficult to deliver through the skin from applying the emulsion such as cream containing them because these drugs are nearly insoluble in aqueous solutions. In this study, the hydrocolloid patch including poorly soluble drugs such as genistein and daidzein was used as the transdermal drug delivery system (TDDS) to deliver them through the skin. It was confirmed that the patches are helpful for the drugs to be absorb much and more deeply than the cream due to the occlusive effect of patch, which was verified from the porcine skin and the confocal microscopy. The hydrocolloid patch is a better way to deliver the poorly soluble drugs through the skin than the general cosmetics such as emulsion-based cream, and is valuable as effective cosmetics due to its convenient usage.

참고문헌 (Reference)

1 N. Motlekar, 101 : 2070-, 2006

2 Z. -R. Huang, 364 : 36-, 2008

3 A. L. T. C. Zampieri, 9 : 1-, 2012

4 Y. Ma, 7 : 559-, 2012

5 J. Tang, 6 : 2429-, 2011

6 Á. E. Daruházi, 48 : 636-, 2008

7 M. Raghunathan, 116 : 3918-, 2012

8 S. Kitagawa, 58 : 398-, 2010

9 A. P. C. Silva, 64 : 32-, 2009

10 J. A. Rothwell, 53 : 4355-, 2005

11 G. P. Martin, 26 : 35-, 2000

12 D. Ladenheimi, 48 : 806-, 1996

13 김수지, "감초 플라보노이드 Liquiritin 및 Liquiritigenin을 담지한 피부전달체인 셀룰로오스 다공성 하이드로젤 제형 개발" 한국고분자학회 38 (38): 676-681, 2014

14 이민혜, "Quercetin과 Rutin의 피부 흡수 증진을 위한 셀룰로오스 다공성 하이드로젤 제형 개발" 한국고분자학회 37 (37): 347-355, 2013