Gellan Gum/Chondroitin Sulfate 조성 유착방지제의 개발

다국어 초록 (Multilingual Abstract)

The purpose of this study was to design the gel composed of gellan gum (GLG) and chondroitin sulfate (CH) and to evaluate their efficacy as an anti-adhesion barrier after abdominal surgery. To improve the mechanical properties of the gels, GLG/CH gels were treated in phosphate buffered saline (PBS) and calcium chloride (CaCl₂) solutions for cross-linking of polymer chains by divalent cations. The physical and mechanical properties of the gels were confirmed by swelling, gel content, gel strength and fourier transform infrared spectroscopy (FTIR) studies. The positive control, negative control and experiment groups were evaluated for prevention of postoperative adhesion formation in rats. The GLG/CH gel (weight ratio of 3:3) showed high effectiveness for the prevention of peritoneal tissue adhesion. In conclusion, the GLG/CH gel can be a good candidate material as a tissue adhesion barrier.

참고문헌 (Reference)

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