덱스트란과 젤라틴을 고정화한 생의학용 산화철 나노입자의 제조 = Fabrication of Magnetite Nanoparticles Immobilized with Dextran and Gelatin for Biomedical Application

다국어 초록 (Multilingual Abstract)

Superparamagnetic iron oxide nanoparticles with suitable biocompatible molecules have been widely used experimentally
for numerous in vivo applications such as magnetic resonance imaging contrast enhancement, tissue engineering,
immunoassay, detoxification of biological fluids, hyperthermia, drug delivery, and in cell separation etc.
Surface-functionalized magnetite nanoparticles are suitable for receptor targeting because of their colloidal stability,
biocompatibility, biodegradability, and non-toxicity for the body. We have prepared gelatin-immobilized magnetite
nanoparticles in order to examine their possible application to molecular imaging. The presence of gelatin on the surface
of nanoparticles was confirmed by observing amine groups using FTIR and ESCA. The size of DGNP particles measured
by TEM and DLS was about 7.5 and 25 nm, respectively. In the cell culture experiment, it is revealed that
DGNPs are more effectively uptaken by fibroblasts when compared to DNP.

참고문헌 (Reference)

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