高麗人蔘 中 酸性多糖 成分이 選擇的 調整劑 및 食鹽不振 改善 役割에 미치는 硏究 = Studies on Selective Modulators and Anti-Anorexigenic Agents in Acidic Polysaccharides of Korean Red Ginseng

다국어 초록 (Multilingual Abstract)

Korean red ginseng powder was found to contain adenosine and an acidic peptide which inhibited epinephrine - induced lipolysis and stimulated insulin- mediated lipogenesis from add glucose. We isolated a toxic substance named "Toxohormone-L" from ascites fluid of patients with various malignant tumors. The toxohormone-L stimulated lipolysis in rat adipocytes and induced anorexia in rats. Both the lipolytic and the anorexigenic actions of toxohormone-L were found to be inhibited by ginsenoside Rb₂ in Korean red ginseng ; The ginsenoside Rb₂inhibits toxohormone-L induced lipolysis in fat cells, while it stimulates adrenocorticotropic hormone (ACTH) stimulated lipolysis. This, all these substances extracted from Korean red ginseng exhibited selective modulations toward the opposite metabolic pathways in rat adipocyte . We call these substances "Selective Modulators".
This study was divised to abserve the role of selective modulator and anti-anorexigenic agents in acidic polysaccharide of Korean red ginseng. A substance that inhibited the lipolytic action of toxohormone-L was isolated and purified from Korean red ginseng powder. This substance had a pectin-like α-1,4-polygalacturonan backbone with some acetoxyl group, and so was an acidic polysaccharide. It inhibited toxohormone-L induced lipolysis in a dose dependent manner at concentrations higher than 10 ㎍/㎖. And the anorexigenic action of toxohormone-L was found to be inhibited by red ginseng in patients with malignant tumor in digestive tract.
These results that both the lipolytic and the anorexigenic actions of toxohormone-L were found to be inhibited by acidic polysaccharide in Korean red ginseng. And suggest that Panax ginseng may protect debilitation of cancer patients through inhibiting the lipolytic and the anorexigenic actions of toxohormone-L.