개의 아토피성 피부염의 피부증상 호발부위의 비만세포분포조사 = Mast cell distribution at predilection sites of atopic dermatitis in normal canine skin

다국어 초록 (Multilingual Abstract)

Mast cell distribution was quantified in acidified toluidine blue sections of normal skin from 8 different sites in 10 dogs and compared to the predilection sites of canine atopic dermatitis. Mast cell counts varied significantly from site to site (p<0.0001) and counts in the superficial dermis were significantly higher than the deeper dermis (p<0.05). The highest mast cells distribution sites were the concave surface of the ear (mean 74.8817.93 per mm2) and the interdigital skin of the forefeet (mean 28.3266.24 per mm2). Counts in these sites were 280% higher than all the other sites. Our results may provide some evidence that cutaneous mast cell distribution may be a factor in the frequent occurrence of ear and foot pruritus in atopic dermatitis. However, the low mast cell count in the predilection sites of atopic dermatitis did not explain the common occurrence of atopic lesions. Therefore, other factors or more complicated pathogenesis may be correlated with these predilection sites.

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