아토피피부염 환자에서 Interleukin-10 , Tumor Necrosis Factor - beta ( TNF-β ) 유전자의 다형성에 관한 연구 = Expression of Genetic Polymorphism of Interleukin-10 ( IL-10 ) and Tumor Necrosis Factor-β ( TNF-β ) in Patients with Atopic Dermatitis아토피피부염 환자에서 Interleukin-10 , Tumor Necrosis Factor - beta ( TNF-β ) 유전자의 다형성에 관한 연구

다국어 초록 (Multilingual Abstract)

Background : Atopie dermatitis (AD) is a common inflammatory skin disease. Atopic dermatitis is associated with increased IL-4, IL-5, IL-10 and IL-13 but decreased 1NF-γand TNF production. IL-10 production has peen implicated in autoimmunity because of its effect on B-cell proliferation and antibody production. The study of IL-10 gene polymorphism is of interest because of the pivotal role of IL-10 In the regulation of inflammatory and immune responses. TNF-β significantly upregulates INF-γ but downregulates IL-5, IL-13 and IgE, which suggests a potential role of TNF-β in the pathogenesis of atopie dermatitis. Objective : We have investigated polymorphism of IL-10 promoter gene and TNF-α gene. Methods : Seventy one patients with atopie dermatitis and one hundred and sixty six normal subjects participated in this study with analysis of polymorphism of IL-10 promoter (-1082), (-819) gene and seventy one partions dermatitis and hundred and forty one normal subject participated in the analysis of polymorphism of TNF-β gene. The patients in this study were recently diagnosed with atopie dermatitis. Results : The frequency of IL-10 promoter (-1082) genotypes (A/A, A/G, G/G), genes (A, G), IL-10 promoter (-819) genotypes (T/T, T/C, C/C) and genes (T, C) did not show any significant difference between atopee dermatitis patients and normal controls. There was no sigmificant defference in the frequency of TNFB genotypes (TNFB^☆1/ /TNFB^☆1, TNFB^☆1/TNFB^☆2, TNFB^☆2/TNFB^☆2) and genes (TNFB^☆1, TNFB^☆2) it patients of atopie dermatitis and normal controls. Conclusion : The result of this study suggest that the other regions of the IL-10 promoter gene and TNFB gene should be investigated for polymorphism of atopie dermatitis. And the difference of IL-10 promoter TNFB gene polymorphism between caucasian and Korean needs to he evaluated.