NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO

다국어 초록 (Multilingual Abstract)

Multiwall carbon nanotubes (MWCNTs) have been widely applied in many ¯elds due to theexcellent physical and chemical properties. As the production and applications of nanotubesexpand, public concern about their potential risks to human health has also raised. Cytotoxicityof MWCNTs was evaluated in this study using a cultured human epithelial cell line A549. Uptakeof MWCNTs by cultured A549 cells was observed by TEM imaging. Dose-dependent decrease ofcell viability showed the cytotoxicity of MWCNTs. Signi¯cant reactive oxygen species (ROS)generation and GSH depletion which reduced the cellular antioxidant level could be the majorfactor of cytotoxicity induced by MWCNTs. MWCNTs seemed to trigger the activation of cellautophagy with the intracellular ATG16L1 level increase as a defense mechanism.

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