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    외상후 스트레스장애와 연관된 인지기능의 결함 = Cognitive Deficits Associated with Posttraumatic Stress Disorder

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    https://www.riss.kr/link?id=A76521301

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    다국어 초록 (Multilingual Abstract) kakao i 다국어 번역

    Objectives In addition to the main symptoms of posttraumatic stress disorder (PTSD), which include reexperience, avoidance and hyperarousal, many patients complain of cognitive deficits and especially in attention and memory. This study was conducted to evaluate the cognitive deficits of survivors of a tragic shooting incident at a frontline guard post. All of the survivors experienced the same accident, and they were homogeneous in terms of age and education level, which are closely associated with cognitive performance.
    Methods We recruited 12 survivors who suffered from PTSD following the same traumatic incident and we also recruited 12 normal volunteers, and we assessed their neurocognitive functions with using a vigilance test, a continuous attention test, a reaction unit test and the Corsi block tapping test in the computerized Vienna Test System, as well as an auditory verbal learning test and complex flgure test In the Rey-Kim Memory Test. Standardized clinical scales, including the Clinician-Admi-nistered PTSD Scale, the Hamilton Depression Rating Scale, the Hamilton Anxiety Scale and the State-Trait Anxiety Scale I and II, were used to assess the involved mental areas and the severity of the PTSD symptoms.
    Results The patient group showed significant impairments in continuous attention, and the visual and auditory information processing time on the Vienna test when compared to the control group. The patient group also showed significant impairments in the verbal memory, visual memory and visuospatial function on the Rey-Kim Memory Test.
    Conclusion In this study, the author reports on the cognitive impairments in patients with PTSD as measured by computerized neurocognitive tests and memory tests. Future studies are needed to determine the changes in cognitive functioning that are related to symptom improvement, as well as the influence of the therapeutic effects on the cognitive improvement.
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    Objectives In addition to the main symptoms of posttraumatic stress disorder (PTSD), which include reexperience, avoidance and hyperarousal, many patients complain of cognitive deficits and especially in attention and memory. This study was conducted ...

    Objectives In addition to the main symptoms of posttraumatic stress disorder (PTSD), which include reexperience, avoidance and hyperarousal, many patients complain of cognitive deficits and especially in attention and memory. This study was conducted to evaluate the cognitive deficits of survivors of a tragic shooting incident at a frontline guard post. All of the survivors experienced the same accident, and they were homogeneous in terms of age and education level, which are closely associated with cognitive performance.
    Methods We recruited 12 survivors who suffered from PTSD following the same traumatic incident and we also recruited 12 normal volunteers, and we assessed their neurocognitive functions with using a vigilance test, a continuous attention test, a reaction unit test and the Corsi block tapping test in the computerized Vienna Test System, as well as an auditory verbal learning test and complex flgure test In the Rey-Kim Memory Test. Standardized clinical scales, including the Clinician-Admi-nistered PTSD Scale, the Hamilton Depression Rating Scale, the Hamilton Anxiety Scale and the State-Trait Anxiety Scale I and II, were used to assess the involved mental areas and the severity of the PTSD symptoms.
    Results The patient group showed significant impairments in continuous attention, and the visual and auditory information processing time on the Vienna test when compared to the control group. The patient group also showed significant impairments in the verbal memory, visual memory and visuospatial function on the Rey-Kim Memory Test.
    Conclusion In this study, the author reports on the cognitive impairments in patients with PTSD as measured by computerized neurocognitive tests and memory tests. Future studies are needed to determine the changes in cognitive functioning that are related to symptom improvement, as well as the influence of the therapeutic effects on the cognitive improvement.

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    참고문헌 (Reference)

    1 정문용, "외상후 스트레스 장애 환자에서 Sertraline이 기억기능에 미치는 영향" 대한정신약물학회 15 (15): 346-353, 2004

    2 전용주, "외상 후 스트레스장애 환자에서 Mirtazapine이 기억기능에 미치는 영향" 대한정신약물학회 13 (13): 254-261, 2002

    3 Schuhfried G, "ienna Test System. Test Management Program. Version 11.00" Dr. Gernot Schuhfried GmbH 1996

    4 Wolfe J, "Use of neuropsychological assessment in posttraumatic stress disorder" 3 : 573-580, 1991

    5 Beckham JC, "Trail making test performance in Vietnam combat veterans with and without posttraumatic stress disorder" 11 : 811-819, 1998

    6 Eichenbaum H, "The hippocampal system and declarative memory in humans and animals: experimental analysis and historical origins. in: Memory systems" Allyn & Bacon 147-201, 1994

    7 Quirk GJ, "Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons" 23 : 8800-8807, 2003

    8 한덕웅, "Spielberger 상태 불안 검사의 표준화" 한국심리학회 111-114, 1993

    9 Kim HK, "Rey-Kim Memory Test" 1999

    10 Archibald HC, "Resistant stress reaction after combat: a 20-year follow-up" 4 : 561-571, 1965

    1 정문용, "외상후 스트레스 장애 환자에서 Sertraline이 기억기능에 미치는 영향" 대한정신약물학회 15 (15): 346-353, 2004

    2 전용주, "외상 후 스트레스장애 환자에서 Mirtazapine이 기억기능에 미치는 영향" 대한정신약물학회 13 (13): 254-261, 2002

    3 Schuhfried G, "ienna Test System. Test Management Program. Version 11.00" Dr. Gernot Schuhfried GmbH 1996

    4 Wolfe J, "Use of neuropsychological assessment in posttraumatic stress disorder" 3 : 573-580, 1991

    5 Beckham JC, "Trail making test performance in Vietnam combat veterans with and without posttraumatic stress disorder" 11 : 811-819, 1998

    6 Eichenbaum H, "The hippocampal system and declarative memory in humans and animals: experimental analysis and historical origins. in: Memory systems" Allyn & Bacon 147-201, 1994

    7 Quirk GJ, "Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons" 23 : 8800-8807, 2003

    8 한덕웅, "Spielberger 상태 불안 검사의 표준화" 한국심리학회 111-114, 1993

    9 Kim HK, "Rey-Kim Memory Test" 1999

    10 Archibald HC, "Resistant stress reaction after combat: a 20-year follow-up" 4 : 561-571, 1965

    11 Gurvits TV, "Performance on visuospatial copying tasks in individuals with chronic posttraumatic stress disorder" 112 : 263-268, 2002

    12 Vasterling JJ, "Olfactory identification in combat-related posttraumatic stress disorder" 13 : 241-253, 2000

    13 Stein MB, "Neuropsychological function in female victims of intimate partner violence with and without posttraumatic stress disorder" 52 : 1079-1088, 2002

    14 Crowell TA, "Neuropsychological findings in combat-related posttraumatic stress disorder" 16 : 310-321, 2002

    15 Vasterling JJ, "Neuropsychological findings in adults with PTSD. in: Neuropsychology of PTSD: biological, cognitive, and clinical perspectives" The Guilford Press 178-207, 2005

    16 Kim SK, "Neurocognitive functions in posttraumatic stress disorder" 10 : 147-158, 2003

    17 Gilbertson MW, "Neurocognitive function in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder" 115 : 484-495, 2006

    18 Gilbertson MW, "Multivariate assessment of explicit memory function in combat veterans with posttraumatic stress disorder" 144 : 413-432, 2001

    19 Sutker PB, "Memory, attention, and executive deficits in POW survivors: contributing biological and psychological factors" 9 : 118-125, 1995

    20 Uddo M, "Memory and attention in combat-related post-traumatic stress disorder" 15 : 43-51, 1993

    21 Koenen KC, "Measures of prefrontal system dysfunction in posttraumatic stress disorder" 45 : 64-78, 2001

    22 Bremner JD, "MRI-based measurement of hippocampal volume in patients with combat related posttraumatic stress disorder" 152 : 973-981, 1995

    23 Macklin ML, "Lower precombat intelligence is a risk factor for posttraumatic stress disorder" 66 : 323-326, 1998

    24 Vermetten E, "Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder" 54 : 693-702, 2003

    25 Baddeley AD, "Human memory: theory and practice" Lawrence Erlbaum Associates 1990

    26 Roozendaal B, "Glucocorticoids interact with the basolateral amygdala beta-adrenoreceptor--cAMP/cAMP/PKA system in influencing memory consolidation" 15 : 553-560, 2002

    27 Foy DW, "Etiology of posttraumatic stress disorder. in: Posttraumatic stress disorder" Allyn & Bacon 29-49, 1992

    28 Woo DK, "Effects of combat related PTSD on memory function: in Vietnam veterans" 6 : 136-146, 1998

    29 Bremner JD, "Does stress damage the brain?" 45 : 797-805, 1999

    30 Bremner JD, "Deficits in short-term memory in posttraumatic stress disorder" 150 : 1015-1019, 1993

    31 Vasterling JJ, "Attention, learning, and memory performances and intellectual resources in Vietnam veterans: PTSD and no disorder comparisons" 19 : 5-14, 2002

    32 Vasterling JJ, "Attention and memory dysfunction in posttraumatic stress disorder" 12 : 125-133, 1998

    33 Shin LM, "Amygdala, medial prefrontal cortex, and hippocampal function in PTSD" 1071 : 67-79, 2006

    34 Lee BY, "A reliability and validity study of a clinician-administered PTSD scale" 38 : 514-522, 1999

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