Increased risk of cardiovascular disease in patients with rosacea: A nationwide retrospective cohort study = Increased risk of cardiovascular disease in patients with rosacea: A nationwide retrospective cohort study

다국어 초록 (Multilingual Abstract)

Background: There is emerging evidence that rosacea is associated with various systemic diseases. However, its association with cardiovascular disease (CVD) remains controversial.
Objectives: We aimed to investigate whether patients with rosacea are at increased risk of developing CVD.
Methods: This retrospective cohort study from the Korean National Health Insurance Service-Health Screening Cohort included patients with newly diagnosed rosacea (n=2,681) and age-, sex-, and index year-matched controls without rosacea (n=26,810) between 2003 and 2014. The primary outcome was subsequent CVD including coronary heart disease and stroke. Multivariable Cox regression analyses were used to evaluate adjusted hazard ratios (aHRs) for subsequent CVD adjusted for major risk factors of CVD.
Results: Compared to controls, patients with rosacea were more likely to have more comorbidities and were less likely to smoke, consume alcohol, and exercise regularly. Rosacea patients displayed an increased risk for CVD (aHR 1.20, 95% CI 1.03-1.40) and coronary heart disease (aHR 1.29, 95% CI 1.05-1.60) compared to controls. The risk for stroke was not significantly increased (aHR 1.12, 95% CI 0.91-1.37).
Conclusion: Patients with rosacea are more likely to develop subsequent CVD adjusted for major CVD risk factors.