미각장애 환자에서 TAS2R38 쓴맛수용체 유전자 단일염기다형성의 역할 = Role of the TAS2R38 Bitter Taste Receptor Gene Single Nucleotide Polymorphism in Patients With Taste Disorders

다국어 초록 (Multilingual Abstract)

Background and Objectives Several studies have shown that three single nucleotide polymorphisms(SNPs) in the TAS2R38 gene demonstrate a strong association with the ability tosense the bitter taste of phenylthiocarbamide (PTC) in. We have previously reported aboutTAS2R38 genotypes in normal volunteers. The aim of this study was to investigate the roleTAS2R38 gene plays in taste disorder by examining SNPs in the TAS2R38 gene in taste disorderpatients.
Subjects and Method Ninety-four patients with taste dysfunction from multiple etiologieswere enrolled. The genotypes were defined by identifying SNPs on the TAS2R38 gene. Theproportion of different TAS2R38 genotypes in the group was compared with that in the normalvolunteers of our previous study. The whole mouth taste threshold tests were performedand the thresholds were compared among the three different genotypic groups.
Results The proportion of each diplotype in taste disorder patients were as follows: PAV/PAV 36.2% (34/94), PAV/AVI 34.0% (32/94), and AVI/AVI 29.8% (28/94). The proportion ofAVI/AVI type was higher in the group than in the normal volunteers (p=0.031). The detectionand recognition thresholds of all four basic tastes were increased in the order of PAV/PAV,PAV/AVI, and AVI/AVI genotypes.
Conclusion The proportion of AVI/AVI homozygous was significantly higher in taste disorderpatients than in the normal volunteers. Our findings suggest that the genotypes of TAS2R38may represent one of the risk factors responsible for the development of taste disorders.

참고문헌 (Reference)

1 이재욱, "한국인에서 성별 및 연령대에 따른 미각역치의 차이" 대한이비인후과학회 57 (57): 692-697, 2014

2 이재욱, "한국인에서 노화에 의한 미각 역치의 변화" 대한이비인후과학회 56 (56): 286-290, 2013

3 예미경, "미맹의 표현형과 유전자형의 관계" 대한이비인후과학회 51 (51): 1124-1128, 2008

4 배재웅, "미각장애와 TAS1R3 및 GNAT3 유전자의 다형성과의 연관성" 한국생명과학회 21 (21): 412-416, 2011

5 임근혜, "미각 장애 환자의 임상적 고찰" 대한이비인후과학회 52 (52): 413-418, 2009

6 Chang WI, "The relationship between phenylthiocarbamide(PTC)and 6-n-propylthiouracil(PROP)taster status and taste thresholds for sucrose and quinine" 51 (51): 427-432, 2006

7 Hong JH, "The relationship between PTC taster status and taste thresholds in young adults" 99 (99): 711-715, 2005

8 Bufe B, "The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception" 15 (15): 322-327, 2005

9 Guo SW, "The genetics of phenylthiocarbamide perception" 28 (28): 111-142, 2001

10 Melis M, "Taste disorders are partly genetically determined : Role of the TAS2R38 gene, a pilot study" 129 (129): E307-E312, 2019

11 Deems DA, "Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center" 117 (117): 519-528, 1991

12 Doty RL, "Relationship of phenylthiocarbamide(PTC)taster status to olfactory and gustatory function in patients with chemosensory disturbances" 41 (41): 685-696, 2016

13 Kim UK, "Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide" 299 (299): 1221-1225, 2003

14 Bartoshuk LM, "PTC/PROP tasting: Anatomy, psychophysics, and sex effects" 56 (56): 1165-1171, 1994

15 Bartoshuk LM, "PROP(6-n-propylthiouracil)supertasters and the saltiness of NaCl" 855 (855): 793-796, 1998

16 Wooding S, "Natural selection and molecular evolution in PTC, a bitter-taste receptor gene" 74 (74): 637-646, 2004

17 Rowan NR, "Impact of bitter taste receptor phenotype upon clinical presentation in chronic rhinosinusitis" 8 (8): 1013-1020, 2018

18 Kim UK, "Genetics of individual differences in bitter taste perception : Lessons from the PTC gene" 67 (67): 275-280, 2005

19 Feeney EL, "Exploring associations between taste perception, oral anatomy and polymorphisms in the carbonic anhydrase (gustin) gene CA6" 128 : 148-154, 2014

20 Ye M, "Diagnosis and treatment of taste disorder" 18 (18): 28-32, 2007

21 Prodi DA, "Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene" 29 (29): 697-702, 2004

22 Duffy VB, "Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake" 28 (28): 1629-1637, 2004