The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta-analysis

다국어 초록 (Multilingual Abstract)

Background Several studies have evaluated the possible association between polymorphisms or variants in Corticotropinreleasing hormone 1 receptor gene (CRHR1) with depression; however, results remain contradictory and heterogeneous.
Objective To our knowledge, we conducted the frst comprehensive systematic review and meta-analysis evaluating the association of the CRHR1 gene and the risk of depression.
Methods A search online was conducted in databases for any CRHR1 genetic association studies in depression. Data were extracted for evaluation of pooled estimates using meta-analytic techniques. Statistical analyses were performed using the Comprehensive Meta-analysis, v2.0 software.
Result A total of 1403 cases and 2353 mentally healthy controls were included in this study. We found a signifcant association of rs242941, rs1876828 and rs242939 variants of the CRHR1 gene with depression. No association of CRHR1 rs110402 and depression was observed.
Conclusion Our meta-analysis shows that some variants of the CRHR1 gene (rs242941, rs1876828 and rs242939) might confer susceptibility to depression. Further studies with larger sample sizes need to be conducted.

참고문헌 (Reference)

1 Rivera M, "The successful search for genetic loci associated with depression" 7 : 92-, 2015

2 Waszczuk MA, "The phenotypic and genetic structure of depression and anxiety disorder symptoms in childhood, adolescence, and young adulthood" 71 : 905-916, 2014

3 Kohli MA, "The neuronal transporter gene SLC6A15 confers risk to major depression" 70 : 252-265, 2011

4 Pompili M, "The hypothalamicpituitary-adrenal axis and serotonin abnormalities : a selective overview for the implications of suicide prevention" 260 : 583-600, 2010

5 Sakai K, "The genomic organization of the human corticotropin-releasing factor type-1 receptor" 219 : 125-130, 1998

6 Kessler RC, "The epidemiology of major depressive disorder : results from the National Comorbidity Survey Replication(NCS-R)" 289 : 3095-3105, 2003

7 Tsatsanis C, "The corticotropin-releasing factor(CRF)family of peptides as local modulators of adrenal function" 64 : 1638-1655, 2007

8 Holsboer F, "The corticosteroid receptor hypothesis of depression" 23 : 477-501, 2000

9 Ray LA, "The CRHR1 gene, trauma exposure, and alcoholism risk : a test of G x E efects" 12 : 361-369, 2013

10 Kim EJ, "Stress efects on the hippocampus : a critical review" 22 : 411-416, 2015

11 Stephens MA, "Stress and the HPA axis : role of glucocorticoids in alcohol dependence" 34 : 468-483, 2012

12 Aguilera G, "Regulation of pituitary corticotropin releasing hormone receptors" 22 : 769-774, 2001

13 Higgins JP, "Quantifying heterogeneity in a metaanalysis" 21 : 1539-1558, 2002

14 Moher D, "Preferred reporting items for systematic reviews and meta-analyses : the PRISMA statement" 6 : e1000097-, 2009

15 Plotsky PM, "Pathways to the secretion of adrenocorticotropin : a view from the portal*" 3 : 1-9, 1991

16 Shyn SI, "Novel loci for major depression identifed by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies" 16 : 202-215, 2011

17 Leszczynska-Rodziewicz A, "No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder" 207 : 140-142, 2013

18 Liu Z, "Negative life events and corticotropinreleasing-hormone receptor1 gene in recurrent major depressive disorder" 3 : 1548-, 2013

19 Dautzenberg FM, "Molecular biology of the CRH receptors—in the mood" 22 : 753-760, 2001

20 DerSimonian R, "Meta-analysis in the design and monitoring of clinical trials" 15 : 1237-1248, 1996

21 Lewis G, "Maternal depression and child and adolescent depression symptoms : an exploratory test for moderation by CRHR1, FKBP5 and NR3C1gene variants" 42 : 121-132, 2012

22 Xiao Z, "Interaction between CRHR1 and BDNF genes increases the risk of recurrent major depressive disorder in Chinese population" 6 : e28733-, 2011

23 Rietschel M, "Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression" 68 : 578-585, 2010

24 Muglia P, "Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts" 15 : 589-601, 2010

25 Shi J, "Genome-wide association study of recurrent early-onset major depressive disorder" 16 : 193-201, 2011

26 Lewis CM, "Genome-wide association study of major recurrent depression in the U. K. population" 167 : 949-957, 2010

27 Zhou H, "Genome-wide association study identifes glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression" 8 : 208-, 2018

28 Smith DJ, "Genome-wide analysis of over 106 000 individuals identifes 9neuroticism-associated loci" 21 : 749-757, 2016

29 Velders FP, "Genetics of cortisol secretion and depressive symptoms : a candidate gene and genome wide association approach" 36 : 1053-1061, 2011

30 Papiol S, "Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment" 104 : 83-90, 2007

31 Welch V, "Extending the PRISMA statement to equity-focused systematic reviews(PRISMA-E 2012) : explanation and elaboration" 70 : 68-89, 2016

32 Maniam J, "Early-life stress, HPA axis adaptation, and mechanisms contributing to later health outcomes" 5 : 73-, 2014

33 Stang A, "Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in metaanalyses" 25 : 603-605, 2010

34 Steckler T, "Corticotropin-releasing factor receptor antagonists in afective disorders and drug dependence—an update" 5 : 147-165, 2006

35 Aguilera G, "Corticotropin releasing hormone receptors : two decades later" 25 : 319-329, 2004

36 Tan EC, "Casecontrol study of glucocorticoid receptor and corticotrophinreleasing hormone receptor gene variants and risk of perinatal depression" 15 : 283-, 2015

37 Egger M, "Bias in metaanalysis detected by a simple, graphical test" 315 : 629-634, 1997

38 Liu Z, "Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression" 404 : 358-362, 2006

39 Licinio J, "Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans" 9 : 1075-1082, 2004

40 Ishitobi Y, "Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population" 159B : 429-436, 2012

41 Sudmant PH, "An integrated map of structural variation in 2, 504 human genomes" 526 : 75-81, 2015

42 Rajeevan H, "ALFRED : the ALelle FREquency database" 31 : 270-271, 2003

43 Ripke S, "A mega-analysis of genome-wide association studies for major depressive disorder" 18 : 497-511, 2013