위암의 세포유전학적 분석 = Cytogenetic Analysis of Stomach Cancer

다국어 초록 (Multilingual Abstract)

To investigate the common specific chromosomal abnormalities of the stomach cancer in Korea, cytogenetic analysis was performed on four primary and one case of lymph node metastatic gastric carcinomas. Hypodiploidy or diploidy were found, however the nonclonal metaphases revealed random loss or gain of one or several different chromosomes in primary cases. In the metastatic case variable
numerical and structural chromosomal abnormalities were found. Nonrandom numerical abnormalities were monosomy on chromosome 7 and 18, and loss of Y chromosme, however hyperdiploidy pattern were found in metastatic case. The nonrandom clone in metastatic case had following structural abnormalities del(1)(q41), dup(1q), 3q+,del(5)(p14), 14p+, 15p+. The common specific chromosomal abnormalities were not found especially in primary cases. In summary, it is presumed that chromosome changes are different by individuals in gastric cancer. So it suggests that mechanism of oncogenesis may be related by personal.