운동양식에 따른 T 림프구와 자연살해 세포의 급성반응 : (AT 시점을 기준으로 나타나는 면역반응역치에 관한 연구) (to Search a Immunological Threshold around AT Level) = The Effects of Exercise Pattern on Acute Response of T Lymphocyte and Natural Killer Cell

다국어 초록 (Multilingual Abstract)

The purpose of this study was to investigate the effects of sustained exercise above and below anaerobic threshold(AT) on exercise-induced acute phase response of T lymphocytes and natural killer cells(NK cell). The Eight healthy graduate students(M, 27 9±2.2 yr) were participated in the exercise sessions. Subjects had no known medical problems and were not taking any medications. All subjects were participated in the exercise sessions on a treadmill, an initial maximal incremental exercise test for determination of anaero bic threshold, and two subsequent bouts that subjects exercise for 40 min at 80%-AT level(below AT level' BAT) and the same amount(301.3±20.5kal) of exercise at 110%-AT level(above AT level' AAT). Venous blood samples were drown at the forearm antecubital vein at pre-exercise, post-exercise, and 30min/90min recovery(15㎖ each), Using anti-CD3 and anti-CD3/anit-CD16+anit-CD56 monoclonal anyibody, T lymphocytes(CD3-positive) and NK cells (CD3 negative/ CD16+CD56-positive) were enumerated with flowcytometery.
In this study, mitogen(PHA) -stimulated T lymphocyte proliferation response and NK cell cytotoxic activity(NKCA) against target cell(K562) were measured to determine the immune cell functions.
There was a significant interactions between intensity(AAT vs BAT) and time in T lymphocytes(CD3+) and NK cell(CD3-/CD16+CD56+) counts(T lymphocytes, P=0.017, NK cells, P=0.049). Also, there were significant changes between all of each sampling interval in AAT although any significant changes existed in BAT on CD3+ cell number. In changing patterns of CD3-/CD16+CD56+ cell counts, AAT was greater than BAT After AAT, T lymphocyte proliferative response was significantly decrease at postexercise(P=0.017), although there was not significant change after BAT. Also, it is appeared that faster recovery pattern followed after BAT than AAT NKCA was higher after sustained exercise in below AT level(30min rec., P=0.002, 90min rec., P=0.006) than AAT during recovery. Thus sustained exercise at slightly AAT resulted in a significant immunosuppressions in T lymphocytes and NK cells. Exercise in BAT can avoiding these immonological disturbance and may decrease chances to undesirable effect of exercise in immune system.

목차 (Table of Contents)

• Abstract
• 1. 서론
• 2. 연구대상 및 방법
• 3. 연구결과
• 4. 논의
• REFERENCE