Oxymetholone의 造血促進效果 = Experimental Study on Hematopoietic Effects of Oxymetholone

국문 초록 (Abstract)

著者는 흰 숫쥐에 蛋白同化 스테로이드인 oxymetholone을 經口的으로 投與하고 投與量에 따르는 赤血球系 造血能의 變動과 好中球, 血小板, 그리고 其他 造血細胞成分에 미치는 影響을 檢討하기 위해 이 實驗을 企圖했으며 다음과 같은 結果를 얻었다. 卽, 體重 ㎏雷 2㎎을 每日 4週間 投與한 實驗群에서는 實驗後 2週부터 網赤血球數가 增加하기 시작하였으며, 對照群에 比하여 骨髓赤芽球 絶對數 및 赤血球 ^59Fe 利用率의 有意한 增加가 있었다. 그리고, 體童 ㎏當 10㎎을 每日 4週間 投與한 實驗群에서는 實驗後 綱赤血球數뿐 아니라 血色素値, hematocrit値 및 赤血球數의 增加도 있었다. 또, 骨髓赤芽球 絶對數와 赤血球 ^59Fe 利用率에 있어서도 2㎎ 投與群보다 多少 높은 增加率을 보여 주었다. 그리고, 體重 ㎏當 20㎎을 每日 4過間 投與한 實驗群에서는 10㎎ 投與群과 大差없는 血色素値, hematocrit値, 赤血球數 및 網赤血球數의 增加가 있었다. 그러나, 10㎎ 投與群에서 볼 수 없었던 好中球 絶對數와 單球 絶封數의 增加를 볼 수 있었으며 아울러 骨隨에 있어서도 亦是 好中球 絶對數와 單球絶 對數의 增加가 있었다. 骨隨赤芽球數의 增加와 赤血球 ^59Fe 利用率의 士昇에 있어서는 10㎎ 投與群과는 큰 差가 없는 것 같았다.

다국어 초록 (Multilingual Abstract)

The hematopoietic effects of oxymetholone in the albino male rats was studied with the following results.
In rats administered oxymetholone orally at a dose of 2㎎/㎏ daily for 4 weeks, reticulocyte count began to rise significantly at second week after the medication. Futrhermore, a marrow absolute erythroid cell count as well as erythrocyte ^59Fe incorporation were appreciably increased as compared with those of the control group.
The peripheral blood of the rats treated with an oral administration of oxymetholone at a dose of 10㎎/㎏ daily for 4 weeks, revealed a significant and gradual enhancement of the reticulocyte, hemoglobin, hematocrit and erythrocytc count at the first week after the administration of the drug.
The marrow absolute erythroid cell count and erythrocyto ^59Fe incorporation also were noticeably increased and their increment were much greater than those of the 2㎎/㎏ group.
In the rats given oxymetholone orally at a dose of 20㎎/㎏ daily for 4 weeks, there were pronounced elevation of the hemoglobin, henlatocrit, erythrocyte count, reticulocyte count, marrow absolute erythroid cell count as well as erythrocyte ^59Fe incorporation. However, their increment were not much different from those of the 10mg/kg group. It was noteworthy that the absolute neutrophil and monocyte count in the peripheral blood as well as the marrow were characteristically enhanced in this particular massive dosage group.