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      The microRNA expression profiles of mouse mesenchymal stem cell during chondrogenic differentiation = The microRNA expression profiles of mouse mesenchymal stem cell during chondrogenic differentiation

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      https://www.riss.kr/link?id=A82520313

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      다국어 초록 (Multilingual Abstract)

      MicroRNAs are potential key regulators in mesenchymal stem cells chondrogenic differentiation. However, there were few reports about the accurate effects of miRNAs on chondrogenic differentiation. To investigate the mechanisms of miRNAs-mediated regul...

      MicroRNAs are potential key regulators in mesenchymal stem cells chondrogenic differentiation. However, there were few reports about the accurate effects of miRNAs on chondrogenic differentiation. To investigate the mechanisms of miRNAs-mediated regulation during the process, we performed miRNAs microarray in MSCs at four different stages of TGF-β3-induced chondrogenic differentiation. We observed that eight miRNAs were significantly up-regulated and five miRNAs were down- regulated. Interestingly, we found two miRNAs clusters, miR-143/145 and miR-132/212, kept on down-regulation in the process. Using bioinformatics approaches, we analyzed the target genes of these differentially expressed miRNAs and found a series of them correlated with the process of chondrogenesis. Furthermore, the qPCR results showed that the up-regulated (or down-regulated) expression of miRNAs were inversely associated with the expression of predicted target genes. Our results first revealed the expression profiles of miRNAs in chondrogenic differentiation of MSCs and provided a new insight on complicated regulation mechanisms of chondrogenesis. [BMB reports 2011; 44(1): 28-33]

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      참고문헌 (Reference)

      1 Lin, E. A, "miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1" 284 : 11326-11335, 2009

      2 Cordes, K. R, "miR-145 and miR-143 regulate smooth muscle cell fate and plasticity" 460 : 705-710, 2009

      3 Ushita, M, "Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells" 17 : 1065-1075, 2009

      4 Hankemeier, S, "Tissue engineering of tendons and ligaments by human bone marrow stromal cells in a liquid fibrin matrix in immunodeficient rats: results of a histologic study" 127 : 815-821, 2007

      5 Smits, P, "The transcription factors L-Sox5 and Sox6 are essential for cartilage formation" 1 : 277-290, 2001

      6 Hornstein, E, "The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development" 438 : 671-674, 2005

      7 Tuddenham, L, "The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells" 580 : 4214-4217, 2006

      8 Helder, M. N, "Stem cells from adipose tissue allow challenging new concepts for regenerative medicine" 13 : 1799-1808, 2007

      9 Akao, Y, "Role of anti-oncomirs miR-143 and -145 in human colorectal tumors" 17 : 398-408, 2010

      10 Butnariu-Ephrat, M, "Resurfacing of goat articular cartilage by chondrocytes derived from bone marrow" 330 : 234-243, 1996

      1 Lin, E. A, "miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1" 284 : 11326-11335, 2009

      2 Cordes, K. R, "miR-145 and miR-143 regulate smooth muscle cell fate and plasticity" 460 : 705-710, 2009

      3 Ushita, M, "Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells" 17 : 1065-1075, 2009

      4 Hankemeier, S, "Tissue engineering of tendons and ligaments by human bone marrow stromal cells in a liquid fibrin matrix in immunodeficient rats: results of a histologic study" 127 : 815-821, 2007

      5 Smits, P, "The transcription factors L-Sox5 and Sox6 are essential for cartilage formation" 1 : 277-290, 2001

      6 Hornstein, E, "The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development" 438 : 671-674, 2005

      7 Tuddenham, L, "The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells" 580 : 4214-4217, 2006

      8 Helder, M. N, "Stem cells from adipose tissue allow challenging new concepts for regenerative medicine" 13 : 1799-1808, 2007

      9 Akao, Y, "Role of anti-oncomirs miR-143 and -145 in human colorectal tumors" 17 : 398-408, 2010

      10 Butnariu-Ephrat, M, "Resurfacing of goat articular cartilage by chondrocytes derived from bone marrow" 330 : 234-243, 1996

      11 Mauck, R. L, "Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading" 6 : 113-125, 2007

      12 박소라, "Preconditioning of mesenchymal stem cells with low-intensity ultrasound for cartilage formation in vivo" MARY ANN LIEBERT INC PUBL 13 (13): 351-360, 200702

      13 Kronenberg, H. M, "PTHrP and skeletal development" 1068 : 1-13, 2006

      14 Oh, C. D, "Opposing role of mitogen- activated protein kinase subtypes, erk-1/2 and p38, in the regulation of chondrogenesis of mesenchymes" 275 : 5613-5619, 2000

      15 Chen, C. Z, "MicroRNAs modulate hematopoietic lineage differentiation" 303 : 83-86, 2004

      16 Xu, N, "MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells" 137 : 647-658, 2009

      17 Esau, C, "MicroRNA-143 regulates adipocyte differentiation" 279 : 52361-52365, 2004

      18 Lakshmipathy, U, "MicroRNA expression pattern of undifferentiated and differentiated human embryonic stem cells" 162 : 1003-1016, 2007

      19 Wienholds, E, "MicroRNA expression in zebrafish embryonic development" 309 : 310-311, 2005

      20 Ortega, F. J, "MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation" 5 : e9022-, 2010

      21 Arinzeh, T. L, "Mesenchymal stem cells for bone repair: preclinical studies and potential orthopedic applications" 10 : 651-665, 2005

      22 Nielsen, J. A, "Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis" 10 : 10-98, 2009

      23 Wakitani, S, "Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees" 10 : 199-206, 2002

      24 Fisher, M. C, "Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation" 25 : 27-39, 2006

      25 Ikeda, T, "Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation" 233 : 337-340, 2005

      26 Goff, L. A, "Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis" 36 : 1354-1369, 2008

      27 Kobayashi, T, "Dicer-dependent pathways regulate chondrocyte proliferation and differentiation" 105 : 1949-1954, 2008

      28 Chen, C. F, "Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets" 18 : 316-327, 2007

      29 Lewis, B. P, "Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets" 120 : 15-20, 2005

      30 Barry, F, "Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components" 268 : 189-200, 2001

      31 이진우, "Chondrogenic Differentiation of Mesenchymal Stem Cells and Its Clinical Applications" 연세대학교의과대학 45 (45): 41-47, 2004

      32 Gaur, T, "Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression" 280 : 33132-33140, 2005

      33 Retting, K. N, "BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation" 136 : 1093-1104, 2009

      34 Wakitani, S, "Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports" 13 : 595-600, 2004

      35 Cheng, A. M, "Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis" 33 : 1290-1297, 2005

      36 Pais, H, "Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level" 162 : 489-494, 2010

      37 Trubiani, O, "Adult mesenchymal stem cells in dental research: a new approach for tissue engineering" 19 : 451-460, 2006

      38 Soleimani, M, "A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow" 4 : 102-106, 2009

      39 Vo, N, "A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis" 10 : 16426-16431, 2005

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      학술지등록 한글명 : BMB reports
      외국어명 : BMB reports
      2024 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2021-01-01 평가 등재학술지 선정 (해외등재 학술지 평가) KCI등재
      2020-12-01 평가 등재후보로 하락 (해외등재 학술지 평가) KCI등재후보
      2013-07-17 학술지명변경 한글명 : BMB reports -> BMB Reports
      외국어명 : BMB reports -> BMB Reports
      KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-09-21 학회명변경 한글명 : 대한생화학ㆍ분자생물학회 -> 생화학분자생물학회
      영문명 : Korean Society Of Medical Biochemistry And Molecular Biology -> Korean Society Of Biochemistry And Molecular Biology
      KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2005-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2002-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1999-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 2.76 0.5 1.94
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.45 1.12 0.646 0.12
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