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Bronchial challenge of allergen(ovalbumin)-sensitized guinea pigs induced a triphasic reduction in specific airways conductance (sGaW) with maximal reductions being observed at 2, 17 and 72hr. accompanied by infiltration of the airways with neutrophil...
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RISS 인기검색어
호흡기질환에서 항 알레르기약제 작용에 대한 연구 : 알레르겐으로 Challenge된 Guinea-Pig에서 Nedocromil-sodium으로 즉시형 및 지연형 기관지천식 반응과 세포침윤의 억제작용 Inhibition by Nedocromil sodium of early and late asthmatic reaction and cellular infiltration provoked by allergen challenged guinea-pigs = A Study of the Effect of Antiallergic Drug in Respiratory Disease
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다국어 초록 (Multilingual Abstract)
Bronchial challenge of allergen(ovalbumin)-sensitized guinea pigs induced a triphasic reduction in specific airways conductance (sGaW) with maximal reductions being observed at 2, 17 and 72hr. accompanied by infiltration of the airways with neutrophils at 17hr. and eosinophils at 17 and 72hr. Nedocromil sodium(100mg m^-1) inhaled before challenge inhibited the 2 and 17hr. sGaw response and the neutrophil influx.
When inhaled 6hr. after challenge, Nedocromil inhibited the 17hr. sGaw response but not neutrophil influx.
The sGaw response and eosinophil accumulation at 72hr. was also inhibited by Nedocromil given at this time. We suggest that Nedocromil sodium inhibit early and late asthmatic reacion and cellular infiltration provoked by allergen challenged guinea-pigs, and being of action of anti-asthmatic drug.
When inhaled 6hr. after challenge, Nedocromil inhibited the 17hr. sGaw response but not neutrophil influx.
The sGaw response and eosinophil accumulation at 72hr. was also inhibited by Nedocromil given at this time. We suggest that Nedocromil sodium inhibit early and late asthmatic reacion and cellular infiltration provoked by allergen challenged guinea-pigs, and being of action of anti-asthmatic drug.
Bronchial challenge of allergen(ovalbumin)-sensitized guinea pigs induced a triphasic reduction in specific airways conductance (sGaW) with maximal reductions being observed at 2, 17 and 72hr. accompanied by infiltration of the airways with neutrophils at 17hr. and eosinophils at 17 and 72hr. Nedocromil sodium(100mg m^-1) inhaled before challenge inhibited the 2 and 17hr. sGaw response and the neutrophil influx.
When inhaled 6hr. after challenge, Nedocromil inhibited the 17hr. sGaw response but not neutrophil influx.
The sGaw response and eosinophil accumulation at 72hr. was also inhibited by Nedocromil given at this time. We suggest that Nedocromil sodium inhibit early and late asthmatic reacion and cellular infiltration provoked by allergen challenged guinea-pigs, and being of action of anti-asthmatic drug.
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