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      천식과 만성폐쇄성폐질환에서 마이크로바이옴 연구 = Current status of microbiome research in asthma and chronic obstructive pulmonary disease

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      https://www.riss.kr/link?id=A102131913

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      다국어 초록 (Multilingual Abstract)

      Asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic airway inflammation resulting in airflow limitation. They include various phenotypes and endotypes in their disease entities. For that reason, they lack proper biomarkers and epoch-making progresses in treatment nowadays. Healthy airway has been believed to be sterile traditionally. However, with the help of nonculture sequencing techniques, researchers discovered that it is full of the commensal and symbiotic microbial flora. Therefore, microbiome has emerged as a possible biomarker and a clue to understand the pathogenesis of airway disease. Microbiome research in asthma has focused on the association between characteristics of microbiome, such as composition and diversity. However, now it refers to the role of microbiome, including Proteobacteria, in the development and pathogenesis of asthma and allergic diseases. Microbiome research in COPD has revealed its different composition according to the existence and severity of the disease. Also, differences in microbiome composition according to exacerbation state or specific treatment of COPD are reported. Therefore, many researchers pay attention to the possible role of microbiome as a biomarker or a treatment target in asthma and COPD. Herein, we review recent studies on microbiome research in asthma and COPD. (Allergy Asthma Respir Dis 2016:4:321-327)
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      Asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic airway inflammation resulting in airflow limitation. They include various phenotypes and endotypes in their disease entities. For that reason, they lack proper biomar...

      Asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic airway inflammation resulting in airflow limitation. They include various phenotypes and endotypes in their disease entities. For that reason, they lack proper biomarkers and epoch-making progresses in treatment nowadays. Healthy airway has been believed to be sterile traditionally. However, with the help of nonculture sequencing techniques, researchers discovered that it is full of the commensal and symbiotic microbial flora. Therefore, microbiome has emerged as a possible biomarker and a clue to understand the pathogenesis of airway disease. Microbiome research in asthma has focused on the association between characteristics of microbiome, such as composition and diversity. However, now it refers to the role of microbiome, including Proteobacteria, in the development and pathogenesis of asthma and allergic diseases. Microbiome research in COPD has revealed its different composition according to the existence and severity of the disease. Also, differences in microbiome composition according to exacerbation state or specific treatment of COPD are reported. Therefore, many researchers pay attention to the possible role of microbiome as a biomarker or a treatment target in asthma and COPD. Herein, we review recent studies on microbiome research in asthma and COPD. (Allergy Asthma Respir Dis 2016:4:321-327)

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      참고문헌 (Reference)

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      9 Brooks C, "The hygiene hypothesis in allergy and asthma: an update" 13 : 70-77, 2013

      10 Goleva E, "The effects of airway microbiome on corticosteroid responsiveness in asthma" 188 : 1193-1201, 2013

      1 심다운, "성인 천식의 바이오마커와 맞춤의학" 대한 소아알레르기 호흡기학회 4 (4): 4-13, 2016

      2 Jackson DJ, "Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children" 178 : 667-672, 2008

      3 Cardenas PA, "Upper airways microbiota in antibiotic-naïve wheezing and healthy infants from the tropics of rural Ecuador" 7 : E46803-, 2012

      4 Mommers M, "Timing of infection and development of wheeze, eczema, and atopic sensitization during the first 2 yr of life: the KOALA Birth Cohort Study" 21 : 983-989, 2010

      5 Huang YJ, "The microbiome in asthma" 135 : 25-30, 2015

      6 Pragman AA, "The lung microbiome in moderate and severe chronic obstructive pulmonary disease" 7 : E47305-, 2012

      7 Teo SM, "The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development" 17 : 704-715, 2015

      8 Cookson W, "The immunogenetics of asthma and eczema: a new focus on the epithelium" 4 : 978-988, 2004

      9 Brooks C, "The hygiene hypothesis in allergy and asthma: an update" 13 : 70-77, 2013

      10 Goleva E, "The effects of airway microbiome on corticosteroid responsiveness in asthma" 188 : 1193-1201, 2013

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      27 Wang Z, "Lung microbiome dynamics in COPD exacerbations" 47 : 1082-1092, 2016

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      29 Sze MA, "Loss of GD1-positive Lactobacillus correlates with inflammation in human lungs with COPD" 5 : E006677-, 2015

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      31 Castro-Nallar E, "Integrating microbial and host transcriptomics to characterize asthma-associated microbial communities" 8 : 50-, 2015

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      36 Fujimura KE, "House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection" 111 : 805-810, 2014

      37 Sze MA, "Host response to the lung microbiome in chronic obstructive pulmonary disease" 192 : 438-445, 2015

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      39 Trompette A, "Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis" 20 : 159-166, 2014

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      42 Herbst T, "Dysregulation of allergic airway inflammation in the absence of microbial colonization" 184 : 198-205, 2011

      43 Pérez-Losada M, "Dual transcriptomic profiling of host and microbiota during health and disease in pediatric asthma" 10 : E0131819-, 2015

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      45 Hilty M, "Disordered microbial communities in asthmatic airways" 5 : E8578-, 2010

      46 Matricardi PM, "Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus" 314 : 999-1003, 1997

      47 Bisgaard H, "Childhood asthma after bacterial colonization of the airway in neonates" 357 : 1487-1495, 2007

      48 Shaheen SO, "Cell mediated immunity after measles in Guinea-Bissau: historical cohort study" 313 : 969-974, 1996

      49 Bager P, "Caesarean delivery and risk of atopy and allergic disease: meta-analyses" 38 : 634-642, 2008

      50 Sze MA, "Bacterial microbiome of lungs in COPD" 9 : 229-238, 2014

      51 Marri PR, "Asthma-associated differences in microbial composition of induced sputum" 131 : 346-352, 2013

      52 Hahn DL, "Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma" 266 : 225-230, 1991

      53 Erb-Downward JR, "Analysis of the lung microbiome in the "healthy" smoker and in COPD" 6 : E16384-, 2011

      54 Strachan DP, "Allergy and family size: a riddle worth solving" 27 : 235-236, 1997

      55 Huang YJ, "Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma" 127 : 372-381, 2011

      56 Huang YJ, "Airway microbiome dynamics in exacerbations of chronic obstructive pulmonary disease" 52 : 2813-2823, 2014

      57 Simpson JL, "Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma" 47 : 792-800, 2016

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      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
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      2013-04-05 학술지명변경 한글명 : 대한소아알레르기및호흡기학회지 -> Allergy Asthma & Respiratory Diseases
      외국어명 : THE Korean Academy of Pediatric Allergy and Respiratory Disease -> 알레르기 천식 호흡기질환
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      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
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      2016 0.34 0.34 0.49
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      0.41 0.41 0.971 0.19
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