Temperature-responsive Hydrogels Synthesized from Photo-Polymerizable Poloxamer Macromers for Topical Skin Moisturizing

다국어 초록 (Multilingual Abstract)

Temperature-responsive hydrogels were fabricated by the photo-polymerization of bis-acryloyl poloxamer tri-block copolymers, and their temperature-responsive behavior and physiological effect on skin were investigated. For this, poloxamer macromers were prepared by end-capping both terminal hydroxyl groups of poloxamer tri-block copolymers with acrylates. They were then photo-polymerized to generate polymeric hydrogels with structural integrity that allowed excellent stability against dilution in an aqueous environment. The resulting hydrogels exhibited dramatic reversible swelling behavior upon changes in temperature. A demonstration experiment, in which the hydrogels were applied topically to the skin, showed that they shrank rapidly as a result of the increase in temperature, owing to the contact with the skin surface, highlighting their effectiveness for instantaneously moisturizing the skin.

참고문헌 (Reference)

1 A. S. Hoffman, 54 : 3-, 2002

2 A. V. Kabanov, 28 : 2303-, 1995

3 J. L. Drury, 24 : 4337-, 2003

4 W. E. Hennink, 54 : 13-, 2002

5 A. V. Kabanov, 82 : 189-, 2002

6 P. Alexandridis, 12 : 2690-, 1996

7 K. W. Chun, 26 : 3319-, 2005

8 H. Hiratani, 5 : 728-, 2005

9 B. K. Mann, 22 : 3045-, 2001

10 M. E. Morales, 60 : 627-, 2009

11 D. Namita, 61 : 421-, 2010

12 T. G. Park, 10 : 82-, 1994

13 T. G. Park, 20 : 517-, 1999

14 G. W. Bos, 25 : 110-, 2001

15 F. Danhier, 161 : 505-, 2012

16 J. Jansen, 12 : 692-, 2012

17 Eunmi Lee, "Smart delivery system for cosmetic ingredients using pH-sensitive polymer hydrogel particles" 한국화학공학회 28 (28): 1347-1350, 2011

18 R. H. Thomas, "Process for separating water from chemical mixtures"

19 T. W. Sohn, "Korea Patent 506543"

20 F. Boberg, "Disposable absorbent article with high collection capacity"

21 C. A. Guzzo, "Dermatological pharmacology. Goodman & Gilman’s The Pharmacological Basis of Therapeutics" McGraw-Hill, Health Professions Division 1593-1616, 1996

22 TAHIRMUHAMMAD NAZIR, "Controlled Ondansetron Release Based on Hydroxyethyl Starch Hydroxyethyl Methacrylate" 대한화학회 33 (33): 4035-4040, 2012