양식 넙치(Paralichthys olivaceus)에 대한 Erythromycin 휴약기간 설정 = Erythromycin Withdrawal Time in Olive Flounder (Paralichthys olivaceus) after Oral Administration

다국어 초록 (Multilingual Abstract)

The withdrawal time of erythromycin in cultured olive flounder was investigated to ensure the food safety of the fish treated with erythromycin. The oral administration of erythromycin was carried out using the experimental diet containing erythromycin(200mg/kg) daily dose of 40 mg/kg body weight. The 45 day experimental period was broken into 7 days of habituation, 8 days of medication and 30 days of additional feeding without antibiotics.
The erythromycin concentration in the flounder muscle had been increased gradually with medication. After 5 days of medication, the concentration increased to its maximum level of 6.05mg/kg. After discontinuing the antibiotic, the erythromycin concentration decreased drastically and day 9 was below 0.1mg/kg. The erythromycin concentration had slowly declined from the 6th to the 20th day after medication and disappeared completely after 25 days. From these results, the time needed to reduce the erythromycin level to the 0.2mg/kg limit adopted by the EU and Japan was suspected to be 4-6 days. Therefore, a reasonable withdrawal time following EU and Japanese regulatory guidelines for erythromycin in the cultured flounder could be estimated to be 10 days.

참고문헌 (Reference)

1 FAO, "Yearbook of fishery statistics" 98 : 1-560, 2006

2 NFRDI(National Fisheries Research and Development Institute), "The guidance of aquatic drug use"

3 MOMAF(Ministry of Maritime Affairs & Fisheries), "Survey on the status of fish culture"

4 MOMAF(Ministry of Maritime Affairs&Fisheries), "Study on the development of HACCP system for fishery products during production and before market"

5 Park, M.S, "Status and prospects of fish diseases in Korea" World Aquaculture 586-, 2002

6 FAO(Food and Agriculture Organizaion of the United Nations), "State of world aquaculture 2006"

7 Hayama,T, "Residues of animal drugs in food" 39 : 6-11, 1998

8 Esposito, A, "Orally administered erythro- mycin in rainbow trout (Oncorhynchus mykiss): Residues in edible tissues and withdrawal time. Antimicrob" 51 : 1043-1047, 2007

9 Ray, W.A, "Oral erythromycin and the risk of sudden death from cardiac causes" 351 : 1089-1096, 2004

10 KFDA, "MRLs for veterinary drugs in foods"

11 KMI(Korea Maritime Institute), "Global maritime affairs & fisheries weekly 16th"

12 KFDA, "Food Code"

13 KFDA(Korea Food&Drug Administration), "Establishment antimicrobials management system for aquaculture"

14 EC(European Communities), "COMMISSION REGULATION No 2593/1999 amending Annexes Ⅰ, Ⅱ and Ⅲ of Council Regulation (EEC) No 2377/90 laying down Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin" 315 : 26-31, 1999

15 KFDA(Korea Food&Drug Administration), "Approval of registration of the animal drug and usage status"

16 Treves-Brown,KM, "Applied fish pharmacology" Kluwer Academic Publ 87-94, 2000

17 Park,J.H, "Analytical method for veterinary drug residues. In: International symposium & workshop on the control of the use of veterinary drug and management of residues in foods of animal origin" NVRQS 137-167, 2004

18 Mi Jung Park, "A New Analytical Method for Erythromycin in Fish by LiquidChromatography/Tandem Mass Spectrometry" 한국식품과학회 17 (17): 508-513, 2008