락토페린이 국내분리 유아 로타바이러스의 MA 104세포 감염에 미치는 영향

다국어 초록 (Multilingual Abstract)

It has long been known that lactoferrin prevents human beings from infection of virus. To prove this activity of lactoferrin, we evaluated the activities of different lactoferrins to an isolate human rotavirus K-21. Bovine lactoferrin inhibited infection of K-21 to MA-104 cell at the concentration of 25.9 ㎛ whereas bovine hydrolysed lactoferrin prevented rotavirus infection at 103.8 ㎛. However human lactoferrin prevented infection of K-21 at the concentration of 217.5 ㎛. These data suggested that lactoferrin activity may be unaffected by the intestinal digestive enzymes and bovine lactoferrin is more active than human lactoferrin with respect to prevention of rotavirus infection.