B 형 간염백신의 면역성에 관한 3 년간 추적 관찰 - 소아와 성인의 면역성을 중심으로 - = Immune Responses of Plasma Derived HB Vaccine for three - years Follow - UPB 형 간염백신의 면역성에 관한 3 년간 추적 관찰 - 소아와 성인의 면역성을 중심으로 -

다국어 초록 (Multilingual Abstract)

This study was performed to assess the effects of HB vaccination and the time of secondary boosting in adults and children. Anti-HBs persistence and boosting responses of plasma derived HB vaccine were estimated for a consecutive three years-follow-up in 12 adults (over 16 years old) and 16 children (under 15 years old) who were negative for five HBV markers with normal transaminase levels hefore immunization, The vaccinations were done at O, lst, and the 6th month for anti-HBs negative persons. The serum transaminases were checked with enzyme kinetic method, The HBs Ag and anti-HBs were checked with EIA technique (mIU/ml) quantitatively at the 1st, 3rd, 6th, 9th, 12th, 24th, and 36th month after primary immunization. The positivities of anti-HBs (over 10 mIU/ml) were 149 at 1st month, 43% at 3rd month, 71%. at 6th month, 93% at 9th month, 93%at 12th month and 79% at 24th month, respectively, The serum levels of anti-HBs showed a progressively decreasing tendency over the course of time. All six anti-HBs negative cases at the 24th month were adults. After secondary boosting immunization for these six cases at the 24th month, the positivities of anti-HBs were remarkably increased to 9395 at the 36th month. In the adult group, The positivities of serum anti-HBs were 17% at the 1st month, 33% at the 3rd month, 50% at the 6th month, 83% at the 9th month, 83% at the 12th month and 50% at the 24th month. After secondary boosting immunization for six cases, the positivity of anti-HBs was 83% (5/6), and the overall positivity of anti-HBs was 92% at the 36th month. In the children group, the positivities of anti-HBs were 1396 at the 1st month, 50% at the 3rd month, 88% at the 6th month, 10% at the 9th month, 100% at the 12th month, 100% at the 24th month and 94% at the 36th month, respectively. The serum anti-HBs was negative only in one case at the 36th month.