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다국어 초록 (Multilingual Abstract)

Purpose: In males, testosterone levels have been implicated in various diseases. Recently, the influence of gut microbialderived compounds on host metabolism has become evident, and it has been suggested that some gut bacteria may be involved in testosterone metabolism. In the present study, we examined the relationship between testosterone levels and gut microbiota in elderly Japanese men.
Materials and Methods: We collected samples from Japanese male subjects suspected of having prostate cancer and underwent prostate biopsies and excluded patients with positive biopsies to avoid the effect of prostate cancer on the gut microbiota.
In total, 54 Japanese males with negative biopsy results were included in our study. The gut microbiota was analyzed by 16S rRNA gene sequencing of bacterial DNA extracted from rectal swabs. Gut microbiota compositions were compared between the two groups according to the level of serum testosterone (above or below 3.5 ng /mL).
Results: The median age of the cohort was 71 years, and the quartile range was 67 to 73 years. We observed no significant difference in alpha or beta diversity, but some bacteria belonging to the phylum Firmicutes (Clostridiales, Turicibacter, and Gemella) were increased in the high testosterone group. Serum testosterone levels positively correlated with the relative amount of Firmicutes (rS=0.3323, p=0.0141), and the amount of Firmicutes affected serum testosterone levels independent of host factors (age, body mass index, triglyceride, and total cholesterol; β=0.770, p=0.0396).
Conclusions: Some intestinal bacteria belonging to the phylum Firmicutes were associated with testosterone levels in elderly males. Therefore, the gut microbiota could affect testosterone metabolism in elderly males.

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참고문헌 (Reference)

1 Amato KR, "The human gut microbiome and health inequities" 118 : e2017947118-, 2021

2 Matsushita M, "The gut microbiota associated with high-Gleason prostate cancer" 112 : 3125-3135, 2021

3 Nishijima S, "The gut microbiome of healthy Japanese and its microbial and functional uniqueness" 23 : 125-133, 2016

4 Pearce KL, "The effect of macronutrients on reproductive hormones in overweight and obese men : a pilot study" 11 : 3059-, 2019

5 Maretti C, "The association of a probiotic with a prebiotic(Flortec, Bracco)to improve the quality/quantity of spermatozoa in infertile patients with idiopathic oligoasthenoteratospermia : a pilot study" 5 : 439-444, 2017

6 Akira Tsujimura, "The Relationship between Testosterone Deficiency and Men’s Health" 대한남성과학회 31 (31): 126-135, 2013

7 Takezawa K, "The Firmicutes/Bacteroidetes ratio of the human gut microbiota is associated with prostate enlargement" 81 : 1287-1293, 2021

8 Cross TL, "Sexual dimorphism of cardiometabolic dysfunction : gut microbiome in the play?" 15 : 70-81, 2018

9 Markle JG, "Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity" 339 : 1084-1088, 2013

10 Shin JH, "Serum level of sex steroid hormone is associated with diversity and profiles of human gut microbiome" 170 : 192-201, 2019