식이제한과 운동부하가 식욕조절관련 호르몬 및 LPL활성에 미치는 영향 = The Effect of Food Restriction and Exercise on Appetite Relating Hormone and Lipoprotein Lipase(LPL) Activity in Rat

다국어 초록 (Multilingual Abstract)

The purpose of this study was to identify the effects of activity of lipoprotein lipase(LPL) and level of appetite control hormone for repeated feeding and exercise during five weeks. Thirty-two Sparague Dawley male rats were divided into 4 groups as follows: control group(CON, n=8), repeated fasting and refeeding group(RER, n=8), RER+exercise group(RER+EX, n=8), 50% volume of pair feed as RER group(PF, n=8). The results were as follows: There was significantly decreased in body weight and fat mass compared to control group(p<.05). The level of leptin was more significant decreased at three groups than control group(p<.05). The level of ghrelin was more significant increased the three groups than control group(p<.05). It is exhibit opposite tendency between the level of leptin to ghrelin. The activity of LPL was significantly decreased only PF group compared to other groups. Meanwhile there was inverse proportion LPL activity to appetite control hormone(r2=0.2383). However there was no correlation LPL activity to appetite control hormone. Consequently, The results were as follows: There was decreased LPL activity in adipose tissue by food restriction and repeated fasting and refeeding including exercise for five weeks. and there was induced to decrease body weight and fat(%) by correlation roles of leptin and ghelin.

참고문헌 (Reference)

1 정원훈, "식이제한이 TALLYHO/JngJ 생쥐의 표현형에 미치는 영향" 대한당뇨병학회 32 (32): 304-316, 2008

2 김민선, "반복적인 금식으로 인한 렙틴 농도의 변동이 렙틴 감수성에 미치는 영향" 대한내분비학회 23 (23): 298-301, 2008

3 박성철, "반복적인 금식으로 인한 렙틴 농도 변동이 렙틴 감수성에 미치는 영향" 대한내분비학회 23 (23): 310-318, 2008

4 Tounian, P., "Weight loss and changes in energy metabolism in massively obese adolescents" 23 : 830-837, 1999

5 Wheeler, J., "Weight cycling in female rats subjected to varying meal patterns" 258 : 124-129, 1990

6 Ben Ounis, O., "Two-month effects of individualized exercise training with or without caloric restriction on plasma adipocytokine levels in obese female adolescents" 70 : 235-241, 2009

7 Miyashita, M., "Twelve-week jogging training increases pre-heparin serum lipoprotein lipase concentrations in overweight/obese middle-aged men" 17 : 21-29,

8 Kumagai, S., "The leptin to adiponectin ratio is a good biomarker for the prevalence of metabolic syndrome, dependent on visceral fat accumulation and endurance fitness in obese patients with diabetes mellitus" 3 : 85-94, 2008

9 Handjieva-Darlenska, T., "The effect of high-fat diet on plasma ghrelin and leptin levels in rats" 65 : 157-164, 2009

10 Kochan, Z., "The decrease of rat postprandial plasma triglycerol concentration after multiple cycles of starvation-refeeding" 33 : 26-29, 2001

11 Powers, S. K., "Rigorous exercise training increases superoxide dismutase activity in ventricular myocardium" 265 (265): 1993

12 Kim, Y. W., "Repeated fasting/refeeding elevates plasma leptin without increasing fat mass in rats" 78 : 459-464, 2003

13 Zofkova, I, "Relationships of hormones of adipose tissue and ghrelin to bone metabolism" 55 : 560-564, 2009

14 Hansen, B. C., "Primary prevention of diabetes mellitus by prevention of obesity in monkeys" 42 : 1809-1814, 1993

15 Maffeis, C., "Postprandial thermogenesis in obese children before and after weight reduction" 46 : 577-583, 1992

16 Fried, S. K., "Nutrition-induced variations in responsiveness to insulin effects on lipoprotein lipase activity in isolated rat fat cells" 120 : 1087-1095, 1990

17 Tessier, S., "Impact of walking on adipose tissue lipoprotein lipase activity and expression in pre-and postmenopausal women" 3 : 191-199, 2010

18 Iverius, P. H. & Brunzell, J. D., "Human adipose tissue lipoprotein lipase: change with feeding and relation to postheparin plasma enzyme" 249 : 107-114, 1985

19 Kong, A., "Higher habitual intake of dietary fat and carbohydrates are associated with lower leptin and higher ghrelin concentrations in overweight and obese postmenopausal women with elevated insulin levels" 29 : 768-776, 2010

20 Perreault. L., "Gender differences in lipoprotein lipase activity after acute exercise" 12 : 241-249, 2004

21 Nagashima, Y., "Effects of fasting and refeeding on some metabolic characteristics of rat brown adipose tissue" 45 : 645-658, 1995

22 Hagobian, T. A., "Effects of exercise on energy-regulating hormones and appetite in men and women" 296 : 233-242, 2009

23 Dos Santos, Z. A., "Effect of food restriction and intense physical training on estrous cyclicity and plasma leptin concentrations in rats" 57 : 1-8, 2011

24 Zwiauer, K. F., "Effect of daytime on resting energy expenditure and thermic effect of food in obese adolescents" 11 : 267-271, 1992

25 Shiraev, T., "Differential effects of restricted versus unlimited high-fat feeding in rats on fat mass, plasma hormones and brain appetite regulators" 21 : 602-609, 2009

26 Oku, H., "Comparative biochemistry and physiology" 145 : 168-178, 2006

27 Kriketos, A. D., "Chisholm DJ, Campbell LV : Exercise increases adiponectin levels and insulin sensitivity in humans" 27 : 629-630, 2004

28 Rigamonti, A. E., "Changes in plasma levels of ghrelin, leptin, and other hormonal and metabolic parameters following standardized breakfast, lunch, and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents" 33 : 633-639, 2010

29 Lass, A., "Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria" 25 : 1089-1097, 1999

30 Usuki, F., "Beneficial effects of mild lifelong dietary restriction on skeletal muscle : prevention of age-related mitochondrial damage, morphological changes, and vulnerability to a chemical toxin" 108 : 1-9, 2004