Occupational Asthma Induced by the Reactive Dye Synozol Red-K 3BS

다국어 초록 (Multilingual Abstract)

Various reactive dyes can elicit occupational asthma in exposed textile industry workers. To date, there has been no report of occupational asthma caused by the red dye Synozol Red-K 3BS (Red-K). Here, we report a 38-year-old male textile worker with occupational asthma and rhinitis induced by inhalation of Red-K. He showed positive responses to Red-K extract on skin-prick testing and serum specific IgE antibodies to Red-K-human serum albumin conjugate were detected using an enzyme-linked immunosorbent assay. A bronchoprovocation test with Red-K extract resulted in significant bronchoconstriction. These findings suggest that the inhalation of the reactive dye Red-K can induce IgE-mediated occupational asthma and rhinitis in exposed workers.

참고문헌 (Reference)

1 Bosshard HF, "The use of a new reactive dye for quantitation of prestained proteins on polyacrylamide gels" 82 : 327-333, 1977

2 Park HS, "The prevalence of specific IgE and IgG to reactive dye-human serum albumin conjugate in workers of a dye factory and neighboring factories" 6 : 63-68, 1991

3 Luczynska CM, "Specific IgE antibodies to reactive dye-albumin conjugates" 95 : 177-186, 1986

4 Park JW, "Role of skin prick test and serological measurement of specific IgE in the diagnosis of occupational asthma resulting from exposure to vinyl sulphone reactive dyes" 58 : 411-416, 2001

5 Park HW, "Outcomes in occupational asthma caused by reactive dye after long-term avoidance" 37 : 225-230, 2007

6 Park HS, "Occupational asthma and IgE antibodies to reactive dyes" 30 : 298-304, 1989

7 Alanko K, "Immediate-type hypersensitivity to reactive dyes" 8 : 25-31, 1978

8 Park JW, "Heterogeneity of IgE epitopes of vinyl sulphone reactive dye: human serum albumin that react with IgE" 31 : 1779-1486, 2001

9 Lee KJ, "Health characteristics and symptom of workers in reactive dye industries" 23 : 338-344, 1990

10 Docker A, "Clinical and immunological investigations of respiratory disease in workers using reactive dyes" 44 : 534-541, 1987

11 Park HS, "Clinical and immunologic evaluations of reactive dye-exposed workers" 87 : 639-649, 1991

12 Nilsson R, "Asthma, rhinitis, and dermatitis in workers exposed to reactive dyes" 50 : 65-70, 1993

13 Koh DH, "Asthma mortality in male workers of the dye industry in Korea" 50 (50): 130-135, 2008

14 Wass U, "An optimized assay of specific IgE antibodies to reactive dyes and studies of immunologic responses in exposed workers" 85 : 642-648, 1990

15 Romano C, "A new case of occupational asthma from reactive dyes with severe anaphylactic response to the specific challenge" 21 : 209-216, 1992