MICROCIRCULATION OF THE LIVER AND ITS RELATION TO LIVER DISORDERS

다국어 초록 (Multilingual Abstract)

Microcirculition in the liver and gastrointestional mucosa is closely associated with the cellular function, and hence, its disturbance relates intimately with the pathogenesis and healing of the liver diseases and the mucosal lesions. Understanding of organ microcirculation is also important for elucidating the mechanism of progression of tumors and action of drugs. Hepatic blood flow, regulated by systemic neuronal and humoral factors, is modified by prostaglandins, platelet-activating factor, and other endogeneous chemical mediators in the liver and GI tract. Endothelium-derived factor, endothelin, that produces vasoconstriction is found to have a role that regulates microcirculation in the liver. These regulators of hepatic and GI-mucosal microcirculation are discussed in terms of data abtained by in vivo microscopy and organ reflectance spectrophotometry in the liver in vivo and hemoglobin-free perfused liver.

목차 (Table of Contents)

• INTRODUCTION
• 1)Organ Reflectance Spectrophotometery for Analyzing Regional Tissue Blood Volume and Oxygenation
• 2)In Vivo Microscopic Analysis of Erythrocyte Flow Velocity and Regional Oxygenation Level.
• 3)Role of hepatic microcirculation in pathogenesis of alcoholic hepatitis in a rat model
• 4)Proof of ischemia and Hypoxemia in the Alcoholic Liver Disease in Men
• 5)Role of disturbed microcirculation in the progression from hepatitis to cirrhosis.
• 6)Regulatory factors for the hepatic microcirculation