자가미세유화를 이용한 이부프로펜 액상제제의 제조와 특성 = Preparation and Characterization of Liquefied Ibuprofen Using Self-Microemulsion Drug Delivery System (SMEDDS)

다국어 초록 (Multilingual Abstract)

Ibuprofen (IBU), is a non-steroidal anti-inflammatory drug, used to treat rheumatoid arthritis, removal of fever and mild to moderate pain. Because of small dosage and very low accumulation in the body, IBU has been used to heal children`s fever. However, IBU was very low solubility in a low pH and water (in water 0.03∼2.5 ㎎/ml). A nanoemulsion containing IBU by means of self-micromulsion drug delivery system (SMEDDS) was prepared in order to enhance the solubility of IBU. The SMEDDS was composed of cosurfactant, oil and surfactant. The solubility of IBU in various components such as cosurfactant, oil and surfactant was examined. Carbitol^(??) (389.99±20.5 ㎎/ml) as a cosurfctant, Labrafil^(??) M1944CS (90.16±1.60 ㎎/ml) as an oil and Cremopher^(??) RH-40(239.01±2.8 ㎎/ml) as a surfactant were used in this study for preparing SMEDDS. Optimized formulation of SMEDDS was obtained by phase diagram which express the section of nanoemulsion formation. The SMEDDS containing IBU had higher dissolution rate than conventional IBU sirups. Thus the SMEDDS was a potential candidate of stable conventional and effective oral dosage form for IBU.

참고문헌 (Reference)

1 "pressurised aerosols formulated as solutions" 3 : 33-40, 1992

2 "alkanediol" int. j. pharm. : 111-, 63-72

3 "The mechanochemical preperation of solid disperse system of ibuprofen-polyethylene glycol" 130 : 25-32, 1996

4 "Synthesis of NiS nanoparticles using a sugar-ester nonionic water-in-oil microemulsion" 58 : 762-767, 2004

5 "Synthesis and characterization of novel dipeptide ester prodrugs of acyclovir" 59 : 2033-2039, 2003

6 "Stereoselective pharmacokinetics of ibuprofen and its lysinate from suppsitiories in rabbits" 199 : 159-166, 2000

7 "Spectrofluorimetric study of the b-cyclodextrin-ibuprofen complex and determination of ibuprofen in phamaceutical preperation and serum" 60 : 235-246, 2003

8 "Solubilization of ibuprofen in aqueous solution" 27 : 279-286, 1997

9 "Self-emulsifying drug delivery system:Assessment of the efficiency of emulsification" 27 : 335-348, 1985

10 "Preparation of solid dosage form containing SMEDDS of simvastatin by microencapsulation," 33 : 121-127, 2003

11 "Preparation and characterization of microemulsion containing ibuprofen" 45 : 634-640, 2001

12 "Preparation and characterization of ibuprofen cetyl alcohol beads by melt solidification technique:Effect of variables" 261 : 57-67, 2003

13 "Post-iontophoresis transport of ibuprofen lysine across rabbit ear skin" 266 : 69-75, 2003

14 "Physician's Desk Reference" Medical Economics Company 53 : 875-889, 1999

15 "Phase studies of oil-in-water phospholipod microemulsions" 84 : 1992

16 "Microemulsions. Colloidal aspects." 4 : 281-300, 1975

17 "Microemulsions-interfacial aspects" 34 : 583-595, 1991

18 "Investigations into the formation and characterization of phospholipid microemulsion IV. Pseudo-ternary phase diagrams of systems containing water-lecithin-alcohol and oil The influence of oil" 125 : 107-116, 1995

19 "Inclusion complex of analgesic and antiinflammatory agents with cyclodextrins Enhancement of dissolution of ibuprofen by 2-hydroxypropyl-b-cyclodextrin" 11-18, 1993

20 "Improved dissolution characteristics of ibuprofen employing self-microemulsifying drug delivery system and their bioavailability in rats" 32 : 27-33, 2002

21 "Formulation and biopharmaceutical evaluation of an investigational lipophilic compound" 87-93, 1992

22 "Formation of cubic structures in microemulsions containing equal volumes of water and oil" 319 : 400-, 1986

23 "Fluorouracil prodrugs for the treatment of proliferative vitreoretinopathy: Formulation in silicone oil and in vitro release of fluorouracil" 259 : 181-192, 2003

24 "Fast dispersible ibuprofen tablets" 15 : 295-305, 2002

25 "Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides" 20 : 91-97, 2003

26 "Enhancement of ibuprofen dissolution via wet granulation with beta-cyclodextrin" 6 : 305-314, 1994

27 "Enhanced solubility of ibuprofen with poloxamer and mentol" 33 : 57-60, 2003

28 "Effect of molecular weights and mixture ratios of polyvinylpyrrolidone on the bioavailability of ipriflavone solid dispersion" 30 : 235-239, 2000

29 "Calorimetric study of CdS nanoparticle formation in w/o microemulsions" 23 : 1077-1081, 2003

30 "Antipyretique activity of ibuprofen syrup in children emergency unit" 16 : 407-410, 2003

31 "A theory of aqueous emulsion. I. Negative interfacial tension at the oil/water interface" 23 : 165-173, 1967

32 "A study on factors influencing the droplet size in nonionic oil-in-water microemulsions" 88 : 417-422, 1992