선택적 니코틴 작용제 ABT-594가 척수손상백서의 배뇨에 미치는 영향 = Effect of ABT-594 a Selective Nicotinic Agonist, on Voiding Function in Spinal Cord Injury Rat

다국어 초록 (Multilingual Abstract)

Purpose: In this study we demonstrate effect of selective nicotinic agonist, ABT-594 on voiding in spinal cord
injury rat.
Materials and Methods: Spinal cord injury rat was made by complete resection of the spinal cord (T8∼9)
and checked cystometry three weeks after injury. In female Sprague-Dawley awake rats, an intravesical catheter
was inserted through the bladder dome and intravenous catheter was inserted to right jugular vein. After the
surgery, cystometry was performed by infusing saline into the bladder (0.08 ml/min). Cumulative doses of ABT-594
(0.01, 0.1, 1, 10 ug/kg) were injected intravenously in spinal cord injury rat at 1 hour intervals.
Results: All dose (0.01∼10 ug/kg) of ABT-594 did not affect the intercontraction interval (ICI), maximal voiding
pressure (MVP), and pressure threshold (PT), and from voiding contraction to non-voiding contraction (from VC
to NVC), voiding volume (VV), residual volume (RV). But moderate dose (1 ug) of ABT-594 significantly decreased
number of non-voiding contraction (55.6±13.7% of control) (p＜0.05).
Conclusion: These result suggest that the nicotinic agonist ABT-594 might in part affect voiding function through
stimulation of serotonergic nerve to lumbosacral level in spinal cord injury rat. (J. Korean Continence Society
2006;10:38-43)
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Key Words: Spinal cord injury, Nicotinic agonist, ABT-594, Bladder

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