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      蒲公英 추출물의 마우스 단회 경구투여 독성 실험

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      https://www.riss.kr/link?id=A100309955

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      다국어 초록 (Multilingual Abstract)

      The object of this study was to obtain acute information (single oral dose toxicity) of Taraxaci Herba (Dried total parts of Taraxacum platycarpum. H.Dahlstedt (Compositae)), has been traditionally used in Korean medicine for treating various inflammatory diseases. In order to observe the 50% lethal dose (LD 50), approximate lethal dosage (ALD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 ㎎/㎏ according to the recommendation of Korea Food and Drug Administration Guidelines. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after single oral treatment of Taraxaci Herba aqueous extracts according to KFDA Guidelines with organ weights and histopathological observations of 12 types of principle organs. After single oral treatment of Taraxaci Herba aqueous extracts, we could not find any mortality and toxicological evidences up to 2,000 ㎎/㎏ treated group, the limited dosages in rodents at body and organ weights, clinical signs, gross and histopathological observations. Except for slight soft feces, which were detected in male mice treated with 2,000 ㎎/㎏ of Taraxaci Herba aqueous extracts at 1 day after end of treatment. The results obtained in this study suggest that the LD 50 and ALD of Taraxaci Herba aqueous extracts in both female and male mice after single oral treatment were considered as over 2,000 ㎎/㎏ because no mortalities were detected up to 2000 ㎎/㎏ that was the highest dose recommended by KFDA and OECD. However, it also observed that the possibility of digestive disorders, like diarrhea when administered over 2,000 ㎎/㎏ of Taraxaci Herba aqueous extracts in the present study, but these possibilities of digestive disorders can be disregard in clinical use because they ate transient in the highest dosages male only.
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      The object of this study was to obtain acute information (single oral dose toxicity) of Taraxaci Herba (Dried total parts of Taraxacum platycarpum. H.Dahlstedt (Compositae)), has been traditionally used in Korean medicine for treating various inflamma...

      The object of this study was to obtain acute information (single oral dose toxicity) of Taraxaci Herba (Dried total parts of Taraxacum platycarpum. H.Dahlstedt (Compositae)), has been traditionally used in Korean medicine for treating various inflammatory diseases. In order to observe the 50% lethal dose (LD 50), approximate lethal dosage (ALD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 ㎎/㎏ according to the recommendation of Korea Food and Drug Administration Guidelines. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after single oral treatment of Taraxaci Herba aqueous extracts according to KFDA Guidelines with organ weights and histopathological observations of 12 types of principle organs. After single oral treatment of Taraxaci Herba aqueous extracts, we could not find any mortality and toxicological evidences up to 2,000 ㎎/㎏ treated group, the limited dosages in rodents at body and organ weights, clinical signs, gross and histopathological observations. Except for slight soft feces, which were detected in male mice treated with 2,000 ㎎/㎏ of Taraxaci Herba aqueous extracts at 1 day after end of treatment. The results obtained in this study suggest that the LD 50 and ALD of Taraxaci Herba aqueous extracts in both female and male mice after single oral treatment were considered as over 2,000 ㎎/㎏ because no mortalities were detected up to 2000 ㎎/㎏ that was the highest dose recommended by KFDA and OECD. However, it also observed that the possibility of digestive disorders, like diarrhea when administered over 2,000 ㎎/㎏ of Taraxaci Herba aqueous extracts in the present study, but these possibilities of digestive disorders can be disregard in clinical use because they ate transient in the highest dosages male only.

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      참고문헌 (Reference)

      1 이미경, "황련과 단삼의 독성평가를 위한 성분분석 및 안정성 시험" 한국생약학회 40 (40): 184-189, 2009

      2 이은, "한약과 민간약물의 독성 및 부작용에 대한 고찰" 대한한방내과학회 23 (23): 222-227, 2002

      3 류종훈, "한방약리학" 신일상사 225-227, 2006

      4 박재수, "포공영 전탕액을 이용한 카드뮴 독성 해독 효과연구" 1 : 76-84, 1997

      5 김석근, "포공영 열수추출물이 진통, 항염작용에 미치는 영향" 13 : 152-161, 1992

      6 하지용, "포공영 약침이 Rat의 Adjuvant 관절염에 미치는 영향" 2 : 135-152, 1999

      7 장인수, "최근 독성 문제가 제기된 한약에 대한 오해와 실제" 67-75, 2007

      8 장인규, "죽력 (竹瀝)의 독성시험 및 약효학적 연구" 2 : 83-101, 1985

      9 이혜정, "종류별 인삼수침엑기스의 독성 연구" 10 : 167-173, 1993

      10 한국식품의약품안전청, "의약품 등의 독성시험기준"

      1 이미경, "황련과 단삼의 독성평가를 위한 성분분석 및 안정성 시험" 한국생약학회 40 (40): 184-189, 2009

      2 이은, "한약과 민간약물의 독성 및 부작용에 대한 고찰" 대한한방내과학회 23 (23): 222-227, 2002

      3 류종훈, "한방약리학" 신일상사 225-227, 2006

      4 박재수, "포공영 전탕액을 이용한 카드뮴 독성 해독 효과연구" 1 : 76-84, 1997

      5 김석근, "포공영 열수추출물이 진통, 항염작용에 미치는 영향" 13 : 152-161, 1992

      6 하지용, "포공영 약침이 Rat의 Adjuvant 관절염에 미치는 영향" 2 : 135-152, 1999

      7 장인수, "최근 독성 문제가 제기된 한약에 대한 오해와 실제" 67-75, 2007

      8 장인규, "죽력 (竹瀝)의 독성시험 및 약효학적 연구" 2 : 83-101, 1985

      9 이혜정, "종류별 인삼수침엑기스의 독성 연구" 10 : 167-173, 1993

      10 한국식품의약품안전청, "의약품 등의 독성시험기준"

      11 최명진, "발효 옻 추출물의 생리활성 및 단회 경구 투여 독성시험" 대한수의학회 50 (50): 187-195, 2010

      12 이지은, "반하의 4주 반복투여독성 평가" 한국실험동물학회 19 (19): 127-141, 2003

      13 뉴엔티퐁타오, "마황, 상륙 및 저령의 독성평가를 위한 성분분석 및 안정성 시험" 한국생약학회 41 (41): 141-146, 2010

      14 함대현, "급성염증유발 동물모델에서 蒲公英의 염증억제 효과" 대한동의병리학회 22 (22): 810-814, 2008

      15 홍석진, "금은화와 포공영 추출물이 첨가된 치약의 치면세균막 및 치은염에 미치는 영향" 25 : 347-355, 2001

      16 경희대학교 약학대학, "건강기능식품의 기능성평가 체계 구축에 대한 연구" 식품의약품안전청 2002

      17 경희대학교 약학대학, "건강기능식품의 기능성평가 체계 구축에 대한 연구" 식품의약품안전청 2002

      18 유효정, "金銀花 추출물의 마우스 단회 경구투여 독성실험" 대한한방내과학회 31 (31): 539-553, 2010

      19 박준식, "蒲公英 추출물이 자궁내막증 유발 白鼠에 미치는 영향" 대한한방부인과학회 19 (19): 69-82, 2006

      20 김인락, "本草學" 圖書出版 永林社 243-245, 2007

      21 Chen, H., "Toxicity studies of Rhizoma Polygonati Odorati" 74 : 221-224, 2001

      22 Koo, H.N., "Taraxacum officinale induces cytotoxicity through TNF-alpha and IL-1alpha secretion in Hep G2 cells" 74 : 1149-1157, 2004

      23 Theoharides, T.C, "Sudden death of a healthy college student related to ephedrine toxicity from a mahuang-containing drink" 17 : 437-439, 1997

      24 Jeong, J.Y., "Studies on immunopotentiating activities of antitumor polysaccharide from aerial parts of Taraxacum platycarpum" 14 : 68-72, 1991

      25 JaeHyun Lee, "Single Subcutaneous Dose Toxicity of Polycan?, a β-Glucan Originated from Aureobasidium in Mice" 한국실험동물학회 21 (21): 299-305, 2005

      26 Hyeung-Sik Lee, "Single Oral Dose Toxicity Study of Water Extractsof Picrorrhiza Rhizoma In ICR Mice" 한국독성학회 22 (22): 117-126, 2006

      27 Organization for Economic C0-Operation and Development, "OECD guideline(423) for the testing of chemicals-acute oral toxicity-acute toxic class method"

      28 U.S. Environmental Protection Agency, "Health Effects Test Guidelines OPPTS 870.100, Acute Toxicity Testing Background"

      29 Plata, E. J., "Growth and hematologic properties of the BALB/wm strain of inbred mice" 22 : 712-720, 1972

      30 Pineda, M.H, "Female reproductive system, In Veterinary endocrinology and reproduction" Lea & Febiger 303-354, 1989

      31 Banks, W.J, "Female reproductive system, In Applied veterinary histology, 2nd ed" Williams & Wilkins 506-526, 1986

      32 Kitts, D., "Efficacy and safety of ginseng" 3 : 473-485, 2000

      33 Yamaguchi, C., "Effects of room temperature on reproduction, body weight and organ weights, food and water intakes, and hematology in mice" 32 : 1-11, 1983

      34 Dourish, C.T, "Effects of drugs on spontaneous motor activity, In Experimental Psychopharmacology" Humana Press 325-334, 1987

      35 Petlevski, R., "Effect of 'antidiabetis' herbal preparation on serum glucose and fructosamine in NOD mice" 75 : 181-184, 2001

      36 Cheong, H., "Desacetylmatricarin, an anti-allergic component from Taraxaum platycarpum" 64 : 577-578, 1998

      37 Irwin, S, "Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse" 13 : 222-257, 1968

      38 손성향, "Combined treatment with colchicine and Herba Taraxaci (Tarazacum mongolicum Hand.-Mazz.) attenuates Behcet's disease-like symptoms in mice and influences the expressions of cytokines" 3 : 713-721, 200305

      39 Wang, G.D., "Clinical and experimental study of burns treated locally with Chinese herbs" 11 : 709-, 1991

      40 Hu, C., "Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro" 51 : 301-310, 2003

      41 Yun, S.I., "Anticoagulant from Taraxacum platycarpum" 66 : 1859-1864, 2002

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2016-03-10 학술지명변경 외국어명 : Korean Journal of Oriental Physiology & Pathology -> Journal of Physiology & Pathology in Korean Medicine KCI등재
      2016-02-24 학회명변경 한글명 : 대한동의병리학회 -> 한의병리학회
      영문명 : The Korean Society Of Oriental Pathology -> The Society of Pathology in Korean Medicine
      KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-09-03 학술지명변경 외국어명 : Korean Journal of Oriental Medical Pathology -> Korean Journal of Oriental Physiology & Pathology KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2003-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2002-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2000-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.47 0.47 0.41
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.35 0.33 0.485 0.09
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