1 "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine 1-phosphate" 99 : 301-312, 1999
2 "Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis" 37 : 1713-1718, 2001
3 "The immunosuppressant FTY720 downregulates sphingosine 1-phosphate G protein-coupled receptors" Epub ahead of print J2004Jan8
4 "The immune modulator FTY720 targets sphingosine 1-phosphate receptors" 277 : 21453-21457, 2002
5 "The immune modulator FTY720 prevents autoimmune diabetes in nonobese diabetic mice" 107 : 30-35, 2003
6 "The balance between sphingosine and sphingosine-1-phosphate is decisive for mast-cell activation after Fc epsilon receptor I triggering" 190 : 1-8, 1999
7 "Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein- coupled receptors" 88 : 115-131, 2000
8 "Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis" 14 : 2255-2265, 2000
9 "Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells" 276 : 31780-31785, 2001
10 "Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products" 285 : 258-267, 2003
1 "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine 1-phosphate" 99 : 301-312, 1999
2 "Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis" 37 : 1713-1718, 2001
3 "The immunosuppressant FTY720 downregulates sphingosine 1-phosphate G protein-coupled receptors" Epub ahead of print J2004Jan8
4 "The immune modulator FTY720 targets sphingosine 1-phosphate receptors" 277 : 21453-21457, 2002
5 "The immune modulator FTY720 prevents autoimmune diabetes in nonobese diabetic mice" 107 : 30-35, 2003
6 "The balance between sphingosine and sphingosine-1-phosphate is decisive for mast-cell activation after Fc epsilon receptor I triggering" 190 : 1-8, 1999
7 "Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein- coupled receptors" 88 : 115-131, 2000
8 "Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis" 14 : 2255-2265, 2000
9 "Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells" 276 : 31780-31785, 2001
10 "Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products" 285 : 258-267, 2003
11 "Role of homeostatic chemokine and sphingosine-1- phosphate receptors in the organization of lymphoid tissue" 987 : 107-116, 2003
12 "Prevention of graft vessel disease by combined FTY720 and Cyclosporin A treatment in the DA to Lewis rat carotid artery transplantation model" 69 : 2525-2530, 2000
13 "Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability" 278 : 47281-47290, 2003
14 "Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY 720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study" 76 : 1079-1084, 2003
15 "Lysophospholipids - receptor revelations" 294 : 1875-1878, 2001
16 "Lymphocyte egress from thymus and peripheral lymphoid organs is sphingosine 1- phosphate receptor-1 dependent" 427 : 355-360, 2004
17 "Longterm islet graft survival in STZ and autoimmune induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720" 73 : 1425-1430, 2002
18 "Ligand- induced trafficking of the sphingosine 1-phosphate receptor EDG-1" 10 : 1179-1190, 1999
19 "Life on the edge" 20 : 473-475, 1999
20 "L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance" 168 : 1579-1589, 2002
21 "Immunosuppressant FTY720 inhibits thymocyte emigration" 30 : 1435-1444, 2000
22 "Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria" 165 : 3250-3259, 2000
23 "Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor sub-types" 309 : 758-768, 2004
24 "HDL induces NO- dependent vasorelaxation via the lysophospholipid receptor S1P3: role of HDL-associated lysophospholipids" 113 : 569-581, 2004
25 "G-protein coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation" 102 : 3665-3667, 2003
26 "Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite" 47 : 208-215, 1994
27 "FTY720: targeting 6-protein- coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity" 14 : 569-575, 2002
28 "FTY720: early clinical experience" 36 (36): 2-8, 2004
29 "FTY720: dissection of membrane receptor- operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects" 33 : 3078-3080, 2001
30 "FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation" 21 : 49-52, 2000
31 "FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function" 4 : 1-7, 2004
32 "FTY720: Altered lymphocyte traffic results in allograft protection" 72 : 764-769, 2001
33 "FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. 1. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing" 160 : 5037-5044, 1998
34 "FTY720, a novel immunosuppressant possessing unique mechanisms. 1. Prolongation of skin allograft survival and synergistic effect in combination with CsA in rats" 28 : 1056-1059, 1996
35 "FTY720, a novel immunomodulator - efficacy and safety results from the first Phase 2a study in de novo renal transplantation" 2004
36 "FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes" 35 : 410-416, 2000
37 "FTY720 immunosuppression impairs effector T-cell peripheral homing without affecting induction, expansion, and memory" 164 : 5761-5770, 2000
38 "FTY720 immunomodulation: optimism for improved transplant regimens" 36 (36): S549-553, 2004
39 "FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression" 33 : 530-531, 2001
40 "Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation" 277 : 6667-6675, 2002
41 "Efficacy of SDZ RAD compared with CsA monotherapy and combined RAD/FTY720 treatment in a murine cardiac allotransplantation model" 9 : 43-49, 2001
42 "Effects of immunosuppressant FTY720 on renal and hepatic hemodynamics in the rat" 74 : 602-610, 2002
43 "Effects of FTY720, a novel immunosuppressant, on experimental autoimmune uveoretinitis in rats" 70 : 7-10, 2000
44 "Effects of FTY720 in MRL-Ipr/Ipr mice: therapeutic potential in systemic lupus erythematosus" 29 : 707-716, 2002
45 "Effect of FTY720, a novel immunosuppressant, on adjuvant- and collagen-induced arthritis in rats" 22 : 323-331, 2000
46 "Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate" 12 : 1589-1598, 1998
47 "Distinct S1P receptor subtypes S1P1 and S1P3 respectively regulate lymphocyte recirculation and heart rate" 279 : 13839-13848, 2004
48 "Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal- regulated kinase pathway" 162 : 3321-3326, 1999
49 "Cell type-specific localization of human cardiac S1P receptors" 50 : 661-670, 2002
50 "CC Chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: modulation by FTY720" 194 : 1875-1881, 2001
51 "Alteration of lymphocyte trafficking by sphingosine 1-phosphate receptor agonists" 296 : 346-349, 2002
52 "Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine 1-phosphate" 489 : 701-777, 1995